Synthesis and biological evaluation of 3-C((E)-2-[125l ]iodoethenyl)-D-allose

A new strategy for the preparation of in vivo stable radioiodinated carbohydrates

M. M. Goodman, R. N. Waterhouse, George Kabalka, F. F. Knapp

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In order to evaluate the in vivo stability of radioiodide attached to the (E)- or transposition of an iodovinyl moiety substituted on carbohydrates designed as new radiopharmaceutics for studying glucose metabolism in the heart and brain, a model [125l]iodoethenyl-substituted carbohydrate has been prepared and evaluated in rats. Radioiodide was introduced into the (E)-position of the ethenyl moiety of 3-C((E)-2-[123l]iodoethenyl-D-allose by [125l]l2 treatment of the corresponding 3-C-((E)-2-tri-n-butyl- stannyl-ethenyl) derivative. Although tissue distribution in rats with (E)-C-3-iodovinyl-D-allose demonstrated low brain and heart uptake, this agent showed low in vivo deiodination which resulted in low thyroid uptake (6.07% dose/gm at 60 min). The low thyroid uptake suggests that additional C-iodovinyl carbohydrates should be evaluated and may be of value as imaging agents.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalNUC Compact
Volume21
Issue number2
StatePublished - Jan 1 1990
Externally publishedYes

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Carbohydrates
Thyroid Gland
Brain
Tissue Distribution
Glucose
allose

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Synthesis and biological evaluation of 3-C((E)-2-[125l ]iodoethenyl)-D-allose : A new strategy for the preparation of in vivo stable radioiodinated carbohydrates. / Goodman, M. M.; Waterhouse, R. N.; Kabalka, George; Knapp, F. F.

In: NUC Compact, Vol. 21, No. 2, 01.01.1990, p. 64-69.

Research output: Contribution to journalArticle

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