Synthesis and Biological Evaluation of a Tetrahydroisoquinoline Derivative Possessing Selective β2-Adrenergic Agonist Activity

Peter F. Kador, R. Venkatraman, Dennis R. Feller, Duane Miller

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This paper reports the synthesis of 4-(3,4,5-trimethoxybenzyI)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (2) and 2-(3,4-dihydroxyphenyl)-3-(3,4,5-trimethoxyphenyl)propylamine (3). The biological activity of these agents relative to that of trimetoquinol (1) in guinea pig atria and guinea pig trachea is reported. The relative activities in relaxation of guinea pig trachea is 1 > 2 > 3 while in the chronotropic response in guinea pig atria the relative order of activity is 1 > 3 ≫ 2.

Original languageEnglish (US)
Pages (from-to)891-894
Number of pages4
JournalJournal of Medicinal Chemistry
Volume20
Issue number7
DOIs
StatePublished - Jul 1 1977

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Tetrahydroisoquinolines
Adrenergic Agonists
Guinea Pigs
Trachea
Tretoquinol
Propylamines
Biological Factors

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

Cite this

Synthesis and Biological Evaluation of a Tetrahydroisoquinoline Derivative Possessing Selective β2-Adrenergic Agonist Activity. / Kador, Peter F.; Venkatraman, R.; Feller, Dennis R.; Miller, Duane.

In: Journal of Medicinal Chemistry, Vol. 20, No. 7, 01.07.1977, p. 891-894.

Research output: Contribution to journalArticle

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