Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer

Veeresa Gududuru, Eunju Hurh, Gangadhar G. Durgam, Seoung Soo Hong, Vineet M. Sardar, Huiping Xu, James T. Dalton, Duane D. Miller

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A series of serine amide phosphates (SAPs) and serine amide alcohols (SAAs) were prepared and evaluated for their in vitro cytotoxicity against five human prostate cancer cell lines. The SAR and biological activity of the synthesized compounds is reported. We describe herein synthesis, SAR, and biological evaluation of a novel series of cytotoxic serine amide phosphates (SAPs) for prostate cancer. These compounds were tested for their cytotoxicity in five human prostate cancer cell lines (DU-145, PC-3, LNCaP, PPC-1, and TSU), and in CHO and RH7777 cells (negative controls). Comparison of anticancer effects of these compounds with a standard chemotherapeutic agent 5-fluorouracil shows that they are very effective in killing prostate cancer cells with low micromolar cytotoxicity and provide us a new lead for the development of drugs for prostate cancer.

Original languageEnglish (US)
Pages (from-to)4919-4923
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number19
DOIs
StatePublished - Oct 4 2004

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Cytotoxicity
Amides
Phospholipids
Prostatic Neoplasms
Cells
Serine
Phosphoserine
Bioactivity
Fluorouracil
Cell Line
Phosphates
Alcohols
CHO Cells
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer. / Gududuru, Veeresa; Hurh, Eunju; Durgam, Gangadhar G.; Hong, Seoung Soo; Sardar, Vineet M.; Xu, Huiping; Dalton, James T.; Miller, Duane D.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 19, 04.10.2004, p. 4919-4923.

Research output: Contribution to journalArticle

Gududuru, Veeresa ; Hurh, Eunju ; Durgam, Gangadhar G. ; Hong, Seoung Soo ; Sardar, Vineet M. ; Xu, Huiping ; Dalton, James T. ; Miller, Duane D. / Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 19. pp. 4919-4923.
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