Synthesis and biological evaluation of water-soluble organogermanium

Sumi Choi, Changwon Oh, Jungsoo Han, Jina Park, Jee Hye Choi, Na Young Min, Kwang Ho Lee, Ae Ja Park, Yeo Jin Kim, Su Jeong Jang, Duck Hyung Lee, Seung Wook Ham

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Interferon (INF) is an effective drug in treating several human diseases. Ge-132, which is the most common and well-studied organic germanium, has been reported to induce INF-γ and has undergone clinical trials with promising preclinical results. However, it has been reported that long-term ingestion or high doses of organic Ge-132 causes similar toxic effects as GeO2 because Ge-132 can be easily contaminated with significant amounts of inorganic germanium during the preparation. In this study, we synthesized the water-soluble organogermanium compound (Ge-OH) without possible contamination with toxic inorganic germanium and showed that Ge-OH is a better INF-γ inducer than Ge-132 by an animal study. Crown

Original languageEnglish (US)
Pages (from-to)1654-1656
Number of pages3
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number4
DOIs
StatePublished - Apr 1 2010

Fingerprint

Germanium
Water
Poisons
Interferons
Interferon Inducers
Crowns
Animals
Contamination
Eating
Clinical Trials
proxigermanium
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Synthesis and biological evaluation of water-soluble organogermanium. / Choi, Sumi; Oh, Changwon; Han, Jungsoo; Park, Jina; Choi, Jee Hye; Min, Na Young; Lee, Kwang Ho; Park, Ae Ja; Kim, Yeo Jin; Jang, Su Jeong; Lee, Duck Hyung; Ham, Seung Wook.

In: European Journal of Medicinal Chemistry, Vol. 45, No. 4, 01.04.2010, p. 1654-1656.

Research output: Contribution to journalArticle

Choi, S, Oh, C, Han, J, Park, J, Choi, JH, Min, NY, Lee, KH, Park, AJ, Kim, YJ, Jang, SJ, Lee, DH & Ham, SW 2010, 'Synthesis and biological evaluation of water-soluble organogermanium', European Journal of Medicinal Chemistry, vol. 45, no. 4, pp. 1654-1656. https://doi.org/10.1016/j.ejmech.2009.12.069
Choi, Sumi ; Oh, Changwon ; Han, Jungsoo ; Park, Jina ; Choi, Jee Hye ; Min, Na Young ; Lee, Kwang Ho ; Park, Ae Ja ; Kim, Yeo Jin ; Jang, Su Jeong ; Lee, Duck Hyung ; Ham, Seung Wook. / Synthesis and biological evaluation of water-soluble organogermanium. In: European Journal of Medicinal Chemistry. 2010 ; Vol. 45, No. 4. pp. 1654-1656.
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AU - Park, Ae Ja

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