Synthesis and biological studies of yohimbine derivatives on human α2C-adrenergic receptors

Suni M. Mustafa, Supriya A. Bavadekar, Guoyi Ma, Bob Moore, Dennis R. Feller, Duane Miller

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A series of yohimbine derivatives was synthesized and evaluated for binding affinity at the human α2C-adrenergic receptors expressed in Chinese hamster ovary cells. It has been found that compound 5 shows a higher affinity for α2C-AR than the parent compound yohimbine 1, thereby illustrating that the nature of the linkers affect binding potencies on these receptors.

Original languageEnglish (US)
Pages (from-to)2758-2760
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number11
DOIs
StatePublished - Jun 2 2005

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Yohimbine
Adrenergic Receptors
Derivatives
Cricetulus
Ovary
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Synthesis and biological studies of yohimbine derivatives on human α2C-adrenergic receptors. / Mustafa, Suni M.; Bavadekar, Supriya A.; Ma, Guoyi; Moore, Bob; Feller, Dennis R.; Miller, Duane.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 11, 02.06.2005, p. 2758-2760.

Research output: Contribution to journalArticle

Mustafa, Suni M. ; Bavadekar, Supriya A. ; Ma, Guoyi ; Moore, Bob ; Feller, Dennis R. ; Miller, Duane. / Synthesis and biological studies of yohimbine derivatives on human α2C-adrenergic receptors. In: Bioorganic and Medicinal Chemistry Letters. 2005 ; Vol. 15, No. 11. pp. 2758-2760.
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