Synthesis and characterization of thermoresponsive-co-biodegradable linear - Dendritic copolymers

Young Shin Kim, Eun Seok Gil, Tao Lowe

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

A novel linear-dendritic copolymer containing thermoresponsive poly(N-isopropylacrylamide) (PNIPAAM), Hydrophobic and biodegradable poly(L-lactic acid) (PLLA), and hydrophilic poly(L-lysine) (PLL) dendrons was designed, synthesized and characterized. The thermoresponsive-co-biodegradable linear-dendritic copolymer was synthesized by 1,3-dicyclohexylcarbodiimide (DCC) coupling reaction of three generation PLL dendron and PNIPAAM grafted with PLLA. UV-vis spectroscopy and dynamic light scattering measurements demonstrated that the linear-dendritic copolymer was thermoresponsive by showing a lower critical solution temperature whose value depended on the linear-dendritic copolymer concentrations. The viscosity and molar mass of the linear-dendritic copolymer decreased with time in PBS (pH = 7.4) solutions indicating that the linear-dendritic copolymer is degradable. FTIR measurements further revealed that the degradation of the linear-dendritic copolymer was due to the hydrolytic degradation of the ester bonds of the PLLA component.

Original languageEnglish (US)
Pages (from-to)7805-7811
Number of pages7
JournalMacromolecules
Volume39
Issue number23
DOIs
StatePublished - Nov 14 2006
Externally publishedYes

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Copolymers
Lactic acid
Phase locked loops
Dicyclohexylcarbodiimide
Dendrimers
Degradation
Molar mass
Dynamic light scattering
Ultraviolet spectroscopy
Lysine
Esters
Viscosity
poly(lactic acid)
Temperature
poly-N-isopropylacrylamide

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Synthesis and characterization of thermoresponsive-co-biodegradable linear - Dendritic copolymers. / Kim, Young Shin; Gil, Eun Seok; Lowe, Tao.

In: Macromolecules, Vol. 39, No. 23, 14.11.2006, p. 7805-7811.

Research output: Contribution to journalArticle

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N2 - A novel linear-dendritic copolymer containing thermoresponsive poly(N-isopropylacrylamide) (PNIPAAM), Hydrophobic and biodegradable poly(L-lactic acid) (PLLA), and hydrophilic poly(L-lysine) (PLL) dendrons was designed, synthesized and characterized. The thermoresponsive-co-biodegradable linear-dendritic copolymer was synthesized by 1,3-dicyclohexylcarbodiimide (DCC) coupling reaction of three generation PLL dendron and PNIPAAM grafted with PLLA. UV-vis spectroscopy and dynamic light scattering measurements demonstrated that the linear-dendritic copolymer was thermoresponsive by showing a lower critical solution temperature whose value depended on the linear-dendritic copolymer concentrations. The viscosity and molar mass of the linear-dendritic copolymer decreased with time in PBS (pH = 7.4) solutions indicating that the linear-dendritic copolymer is degradable. FTIR measurements further revealed that the degradation of the linear-dendritic copolymer was due to the hydrolytic degradation of the ester bonds of the PLLA component.

AB - A novel linear-dendritic copolymer containing thermoresponsive poly(N-isopropylacrylamide) (PNIPAAM), Hydrophobic and biodegradable poly(L-lactic acid) (PLLA), and hydrophilic poly(L-lysine) (PLL) dendrons was designed, synthesized and characterized. The thermoresponsive-co-biodegradable linear-dendritic copolymer was synthesized by 1,3-dicyclohexylcarbodiimide (DCC) coupling reaction of three generation PLL dendron and PNIPAAM grafted with PLLA. UV-vis spectroscopy and dynamic light scattering measurements demonstrated that the linear-dendritic copolymer was thermoresponsive by showing a lower critical solution temperature whose value depended on the linear-dendritic copolymer concentrations. The viscosity and molar mass of the linear-dendritic copolymer decreased with time in PBS (pH = 7.4) solutions indicating that the linear-dendritic copolymer is degradable. FTIR measurements further revealed that the degradation of the linear-dendritic copolymer was due to the hydrolytic degradation of the ester bonds of the PLLA component.

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