Synthesis and evaluation of a new series of 17α-[123I]iodovinyl estradiols

George Kabalka, Timothy M. Shoup, Gregory B. Daniel, Mark M. Goodman

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A series of 17α-substituted estradiols was synthesized in which the stereochemical characteristics of carbons 20 and 21 were modified. It was found that the (Z)-isomer demonstrated more favorable receptor binding affinity than the corresponding (E)-isomer. (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)279-287
Number of pages9
JournalNuclear Medicine and Biology
Volume27
Issue number3
DOIs
StatePublished - Apr 1 2000
Externally publishedYes

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Estradiol
Carbon

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Synthesis and evaluation of a new series of 17α-[123I]iodovinyl estradiols. / Kabalka, George; Shoup, Timothy M.; Daniel, Gregory B.; Goodman, Mark M.

In: Nuclear Medicine and Biology, Vol. 27, No. 3, 01.04.2000, p. 279-287.

Research output: Contribution to journalArticle

Kabalka, George ; Shoup, Timothy M. ; Daniel, Gregory B. ; Goodman, Mark M. / Synthesis and evaluation of a new series of 17α-[123I]iodovinyl estradiols. In: Nuclear Medicine and Biology. 2000 ; Vol. 27, No. 3. pp. 279-287.
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