Synthesis, characterization, and long-term stability of hollow polymer nanocapsules with nanometer-thin walls

Sergey A. Dergunov, Katrina Kesterson, Wei Li, Zhao Wang, Eugene Pinkhassik

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Hollow polymer nanocapsules are produced by the polymerization within hydrophobic interior of lipid bilayers that act as temporary self-assembled scaffolds. Pore-forming templates are codissolved with monomers in the bilayers to create pores with controlled size and chemical environment. Polymerization was monitored with UV spectroscopy and dynamic light scattering. High-resolution magic angle spinning NMR characterization provided detailed structural information about nanocapsules. Spherical shape was confirmed by electron microscopy. Medium-sized molecules can be entrapped within porous nanocapsules. No release of encapsulated molecules was observed within 240 days.

Original languageEnglish (US)
Pages (from-to)7785-7792
Number of pages8
JournalMacromolecules
Volume43
Issue number18
DOIs
StatePublished - Sep 28 2010

Fingerprint

Nanocapsules
Polymers
Polymerization
Magic angle spinning
Molecules
Lipid bilayers
Dynamic light scattering
Ultraviolet spectroscopy
Scaffolds
Electron microscopy
Monomers
Nuclear magnetic resonance

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Synthesis, characterization, and long-term stability of hollow polymer nanocapsules with nanometer-thin walls. / Dergunov, Sergey A.; Kesterson, Katrina; Li, Wei; Wang, Zhao; Pinkhassik, Eugene.

In: Macromolecules, Vol. 43, No. 18, 28.09.2010, p. 7785-7792.

Research output: Contribution to journalArticle

Dergunov, Sergey A. ; Kesterson, Katrina ; Li, Wei ; Wang, Zhao ; Pinkhassik, Eugene. / Synthesis, characterization, and long-term stability of hollow polymer nanocapsules with nanometer-thin walls. In: Macromolecules. 2010 ; Vol. 43, No. 18. pp. 7785-7792.
@article{f714ae2f7eda4e5a82c2811bbfc0f971,
title = "Synthesis, characterization, and long-term stability of hollow polymer nanocapsules with nanometer-thin walls",
abstract = "Hollow polymer nanocapsules are produced by the polymerization within hydrophobic interior of lipid bilayers that act as temporary self-assembled scaffolds. Pore-forming templates are codissolved with monomers in the bilayers to create pores with controlled size and chemical environment. Polymerization was monitored with UV spectroscopy and dynamic light scattering. High-resolution magic angle spinning NMR characterization provided detailed structural information about nanocapsules. Spherical shape was confirmed by electron microscopy. Medium-sized molecules can be entrapped within porous nanocapsules. No release of encapsulated molecules was observed within 240 days.",
author = "Dergunov, {Sergey A.} and Katrina Kesterson and Wei Li and Zhao Wang and Eugene Pinkhassik",
year = "2010",
month = "9",
day = "28",
doi = "10.1021/ma1012418",
language = "English (US)",
volume = "43",
pages = "7785--7792",
journal = "Macromolecules",
issn = "0024-9297",
publisher = "American Chemical Society",
number = "18",

}

TY - JOUR

T1 - Synthesis, characterization, and long-term stability of hollow polymer nanocapsules with nanometer-thin walls

AU - Dergunov, Sergey A.

AU - Kesterson, Katrina

AU - Li, Wei

AU - Wang, Zhao

AU - Pinkhassik, Eugene

PY - 2010/9/28

Y1 - 2010/9/28

N2 - Hollow polymer nanocapsules are produced by the polymerization within hydrophobic interior of lipid bilayers that act as temporary self-assembled scaffolds. Pore-forming templates are codissolved with monomers in the bilayers to create pores with controlled size and chemical environment. Polymerization was monitored with UV spectroscopy and dynamic light scattering. High-resolution magic angle spinning NMR characterization provided detailed structural information about nanocapsules. Spherical shape was confirmed by electron microscopy. Medium-sized molecules can be entrapped within porous nanocapsules. No release of encapsulated molecules was observed within 240 days.

AB - Hollow polymer nanocapsules are produced by the polymerization within hydrophobic interior of lipid bilayers that act as temporary self-assembled scaffolds. Pore-forming templates are codissolved with monomers in the bilayers to create pores with controlled size and chemical environment. Polymerization was monitored with UV spectroscopy and dynamic light scattering. High-resolution magic angle spinning NMR characterization provided detailed structural information about nanocapsules. Spherical shape was confirmed by electron microscopy. Medium-sized molecules can be entrapped within porous nanocapsules. No release of encapsulated molecules was observed within 240 days.

UR - http://www.scopus.com/inward/record.url?scp=78651276695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78651276695&partnerID=8YFLogxK

U2 - 10.1021/ma1012418

DO - 10.1021/ma1012418

M3 - Article

VL - 43

SP - 7785

EP - 7792

JO - Macromolecules

JF - Macromolecules

SN - 0024-9297

IS - 18

ER -