Synthesis of a dicyclobutylideneethane derivative via sequential palladium-catalyzed Miyaura borylation and Suzuki coupling

George Kabalka, Min Liang Yao

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

An efficient synthesis of a dicyclobutylideneethane derivative was achieved using a palladium-catalyzed reaction of a substituted (bromomethylene)cyclobutane with bis(pinacolato)diboron. The reaction mechanism was investigated in detail. The Suzuki cross-coupling reaction of a (bromomethylene)cyclobutane with arylboronic acid was also achieved.

Original languageEnglish (US)
Pages (from-to)7885-7887
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number43
DOIs
StatePublished - Oct 20 2003
Externally publishedYes

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Cyclobutanes
Palladium
Derivatives
Cross Reactions
Acids
bis(pinacolato)diboron

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Synthesis of a dicyclobutylideneethane derivative via sequential palladium-catalyzed Miyaura borylation and Suzuki coupling. / Kabalka, George; Yao, Min Liang.

In: Tetrahedron Letters, Vol. 44, No. 43, 20.10.2003, p. 7885-7887.

Research output: Contribution to journalArticle

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