Synthesis of a Potential Boron Neutron Capture Therapy Agent: 1-Amino-cyclobutane-1-carboxylic Acid Bearing a Butylboronic Acid Side Chain

George Kabalka, Min Liang Yao

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A novel boronated aminocyclobutanecarboxylic acid was synthesized for potential use in neutron capture therapy. The synthesis involves the preparation of tosylate 5, which was then converted to an amino acid using Bucherer-Strecker methodology. The molecule was modeled after the unnatural amino acid, 1-aminocyclobutane-1-carboxylic acid, which has shown high uptake in brain tumors.

Original languageEnglish (US)
Pages (from-to)2890-2893
Number of pages4
JournalSynthesis
Issue number18
DOIs
StatePublished - Jan 1 2003

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Bearings (structural)
Cyclobutanes
Boron
Carboxylic Acids
Carboxylic acids
Amino acids
Neutrons
Amino Acids
Acids
Tumors
Brain
Molecules
n-butylboronic acid

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

Cite this

Synthesis of a Potential Boron Neutron Capture Therapy Agent : 1-Amino-cyclobutane-1-carboxylic Acid Bearing a Butylboronic Acid Side Chain. / Kabalka, George; Yao, Min Liang.

In: Synthesis, No. 18, 01.01.2003, p. 2890-2893.

Research output: Contribution to journalArticle

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