Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus

Isaac Donkor, M. Lee Sanders

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The reported diketopiperazine calpain inhibitor, cis-L-L-3,6-bis-(4-hydroxybenzyl)-1,4-dimethylpiperazine-2,5-dione 1, and its analogues 3 and 4 were synthesized from the corresponding amino acids. The previously assigned structure of 1 is confirmed but neither synthetic 1 nor its N-methylphenylalanine analogues 3 and 4 inhibit porcine erythrocyte calpain I.

Original languageEnglish (US)
Pages (from-to)2647-2649
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number19
DOIs
StatePublished - Oct 8 2001

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Diketopiperazines
Streptomyces griseus
Calpain
Swine
Erythrocytes
Amino Acids
1,4-dimethylpiperazine
calpain inhibitors

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus. / Donkor, Isaac; Sanders, M. Lee.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 19, 08.10.2001, p. 2647-2649.

Research output: Contribution to journalArticle

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