Synthesis of Fluorinated Pyrimidines and Triazines

Mathias P. Mertes, Souheil E. Saheb, Duane Miller

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The synthesis of fiuorinated pyrimidines and triazines as potential thymidylate synthease inhibitors was accomplished by treating the appropriate earbonyl compound with sulfur teteafluoride in the presence of hydrofluoric acid. The anomers of.a5-trifluoromethyl-6-aza-2፴-deoxyuridine were prepared by conventional procedures from 5-trifluoromethyl-6-azauracil. Some preliminary biological results are presented.

Original languageEnglish (US)
Pages (from-to)876-881
Number of pages6
JournalJournal of Medicinal Chemistry
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1966
Externally publishedYes

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Hydrofluoric Acid
Sulfur Compounds
Pyrimidines
Triazines
azauracil
6-aza-2'-deoxyuridine

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

Cite this

Synthesis of Fluorinated Pyrimidines and Triazines. / Mertes, Mathias P.; Saheb, Souheil E.; Miller, Duane.

In: Journal of Medicinal Chemistry, Vol. 9, No. 6, 01.01.1966, p. 876-881.

Research output: Contribution to journalArticle

Mertes, Mathias P. ; Saheb, Souheil E. ; Miller, Duane. / Synthesis of Fluorinated Pyrimidines and Triazines. In: Journal of Medicinal Chemistry. 1966 ; Vol. 9, No. 6. pp. 876-881.
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