Synthesis of substituted tetrahydropyrimido‐[4, 5‐b][1, 7]naphthyridines as potential antitumor agents

Aleem Gangjee, Isaac Donkor

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The synthesis of two linear trisubstituted 6, 7, 8, 9‐tetrahydropyrimido[4, 5‐b][1, 7]naphthyridines 1 and 3 were accomplished by the regiospecific cyclocondensation of two disubstituted 6‐aminopyrimidines 10 and 11 with the ketoaldehyde 1‐benzyl‐4‐hydroxymethylene‐3‐piperidone. Catalytic debenzylation of 1 afforded the disubstituted compound 2. The linear structures of 1–3 were established by 1H nmr and 13C nmr.

Original languageEnglish (US)
Pages (from-to)705-708
Number of pages4
JournalJournal of Heterocyclic Chemistry
Volume26
Issue number3
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Naphthyridines
Antineoplastic Agents

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Synthesis of substituted tetrahydropyrimido‐[4, 5‐b][1, 7]naphthyridines as potential antitumor agents. / Gangjee, Aleem; Donkor, Isaac.

In: Journal of Heterocyclic Chemistry, Vol. 26, No. 3, 01.01.1989, p. 705-708.

Research output: Contribution to journalArticle

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