Synthesis of 15O-labeled butanol via organoborane chemistry

George Kabalka, R. M. Lambrecht, M. Sajjad, J. S. Fowler, S. A. Kunda, G. W. McCollum, R. MacGregor

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O2-15O with tri-n-butylborane and tri-sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of 15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.

Original languageEnglish (US)
Pages (from-to)853-855
Number of pages3
JournalThe International Journal Of Applied Radiation And Isotopes
Volume36
Issue number11
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

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Cerebrovascular Circulation
Butanols
1-Butanol
chromatography
Butenes
Gas Chromatography
Chromatography
chemistry
Oxygen
flow measurement
synthesis
blood flow
gas chromatography
tetrahydrofuran
reaction products
Column chromatography
Flow measurement
Reaction products
Gas chromatography
oxygen

All Science Journal Classification (ASJC) codes

  • Radiation
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Kabalka, G., Lambrecht, R. M., Sajjad, M., Fowler, J. S., Kunda, S. A., McCollum, G. W., & MacGregor, R. (1985). Synthesis of 15O-labeled butanol via organoborane chemistry. The International Journal Of Applied Radiation And Isotopes, 36(11), 853-855. https://doi.org/10.1016/0020-708X(85)90017-1

Synthesis of 15O-labeled butanol via organoborane chemistry. / Kabalka, George; Lambrecht, R. M.; Sajjad, M.; Fowler, J. S.; Kunda, S. A.; McCollum, G. W.; MacGregor, R.

In: The International Journal Of Applied Radiation And Isotopes, Vol. 36, No. 11, 01.01.1985, p. 853-855.

Research output: Contribution to journalArticle

Kabalka, G, Lambrecht, RM, Sajjad, M, Fowler, JS, Kunda, SA, McCollum, GW & MacGregor, R 1985, 'Synthesis of 15O-labeled butanol via organoborane chemistry', The International Journal Of Applied Radiation And Isotopes, vol. 36, no. 11, pp. 853-855. https://doi.org/10.1016/0020-708X(85)90017-1
Kabalka, George ; Lambrecht, R. M. ; Sajjad, M. ; Fowler, J. S. ; Kunda, S. A. ; McCollum, G. W. ; MacGregor, R. / Synthesis of 15O-labeled butanol via organoborane chemistry. In: The International Journal Of Applied Radiation And Isotopes. 1985 ; Vol. 36, No. 11. pp. 853-855.
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