Synthesis of ureidomuraymycidine derivatives for structure-activity relationship studies of muraymycins

Bilal A. Aleiwi, Christopher M. Schneider, Michio Kurosu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Figure Persented: One of the key constituents of the muraymycins is the 6-membered cyclic guanidine, (2S,3S)-muraymycidine (or epi-capreomycidine). In order to diversify the structure of the oligopeptide moiety of the muraymycins for thorough structure-activity relationship studies, we have developed a highly stereoselective synthesis of ureidomuraymycidine derivatives with the lactone 4a.

Original languageEnglish (US)
Pages (from-to)3859-3867
Number of pages9
JournalJournal of Organic Chemistry
Volume77
Issue number8
DOIs
StatePublished - Apr 20 2012

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Oligopeptides
Guanidine
Lactones
Derivatives
capreomycidine

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Synthesis of ureidomuraymycidine derivatives for structure-activity relationship studies of muraymycins. / Aleiwi, Bilal A.; Schneider, Christopher M.; Kurosu, Michio.

In: Journal of Organic Chemistry, Vol. 77, No. 8, 20.04.2012, p. 3859-3867.

Research output: Contribution to journalArticle

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