Synthetic studies toward the generation of uridine-amino alcohol-based small optimized libraries

Michio Kurosu, Prabagaran Narayanasamy, Dean C. Crick

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

An efficient synthesis of a versatile scaffold 3, anti-2-chloro-3-hydroxy ester can be achieved via a boron mediated diastereofacial anti-aldol reaction of 2-(N methylbenzyl-N 2,4,6-trimethylbenzyl)-amino-l-phenylpropanol chloroester 1 and the uridyl aldehyde derivative 2. Generation of uridine-amino alcohol-based library is demonstrated by using the scaffold 3.

Original languageEnglish (US)
Pages (from-to)339-352
Number of pages14
JournalHeterocycles
Volume72
DOIs
StatePublished - Apr 13 2007

Fingerprint

Amino Alcohols
Boron
Uridine
Aldehydes
Scaffolds
Libraries
Esters
Derivatives
3-hydroxybutanal
1-phenylpropanol

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Cite this

Synthetic studies toward the generation of uridine-amino alcohol-based small optimized libraries. / Kurosu, Michio; Narayanasamy, Prabagaran; Crick, Dean C.

In: Heterocycles, Vol. 72, 13.04.2007, p. 339-352.

Research output: Contribution to journalArticle

Kurosu, Michio ; Narayanasamy, Prabagaran ; Crick, Dean C. / Synthetic studies toward the generation of uridine-amino alcohol-based small optimized libraries. In: Heterocycles. 2007 ; Vol. 72. pp. 339-352.
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