Systemic AA amyloidosis in the common marmoset

E. Ludlage, C. L. Murphy, S. M. Davern, Alan Solomon, D. T. Weiss, D. Glenn-Smith, S. Dworkin, K. G. Mansfield

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The common marmoset (Callithrix jacchus) is a small New World primate native to Brazil that has been used extensively in biomedical research. A retrospective analysis of archived hematoxylin and eosinstained tissue sections and clinical records was conducted at the New England Primate Research Center on 86 marmosets more than 1 year of age that were euthanized during the past decade because of morbidity and failure to thrive. Approximately 17% (15 of 86) were found to have amyloid deposits in one or more organs, including the liver, adrenal glands, kidneys, and intestine. This material was shown by amino acid sequence analysis to be composed of serum amyloid A (SAA)-related protein. This type of amyloidosis, designated AA or "secondary," is associated typically with an inflammatory process that induces elevated levels of the SAA amyloidogenic precursor molecule. Notably, there were no significant pathologic differences or other distinguishing features in animals with amyloid versus those without; furthermore, on the basis of the limited number of serum specimens available for analysis, the SAA concentrations in the two groups were comparable, thus suggesting the possible inheritable nature of the disorder. In this respect, the common marmoset provides a unique experimental model for study of the pathogenesis and treatment of AA and other forms of systemic amyloidosis.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalVeterinary Pathology
Volume42
Issue number2
DOIs
StatePublished - Mar 1 2005

Fingerprint

Serum Amyloid A Protein
amyloidosis
Callithrix
Callithrix jacchus
Amyloidosis
amyloid
Primates
failure to thrive
Failure to Thrive
New England
Callitrichidae
New England region
adrenal glands
biomedical research
Protein Sequence Analysis
Amyloid Plaques
Hematoxylin
Adrenal Glands
Amyloid
Intestines

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Ludlage, E., Murphy, C. L., Davern, S. M., Solomon, A., Weiss, D. T., Glenn-Smith, D., ... Mansfield, K. G. (2005). Systemic AA amyloidosis in the common marmoset. Veterinary Pathology, 42(2), 117-124. https://doi.org/10.1354/vp.42-2-117

Systemic AA amyloidosis in the common marmoset. / Ludlage, E.; Murphy, C. L.; Davern, S. M.; Solomon, Alan; Weiss, D. T.; Glenn-Smith, D.; Dworkin, S.; Mansfield, K. G.

In: Veterinary Pathology, Vol. 42, No. 2, 01.03.2005, p. 117-124.

Research output: Contribution to journalArticle

Ludlage, E, Murphy, CL, Davern, SM, Solomon, A, Weiss, DT, Glenn-Smith, D, Dworkin, S & Mansfield, KG 2005, 'Systemic AA amyloidosis in the common marmoset', Veterinary Pathology, vol. 42, no. 2, pp. 117-124. https://doi.org/10.1354/vp.42-2-117
Ludlage E, Murphy CL, Davern SM, Solomon A, Weiss DT, Glenn-Smith D et al. Systemic AA amyloidosis in the common marmoset. Veterinary Pathology. 2005 Mar 1;42(2):117-124. https://doi.org/10.1354/vp.42-2-117
Ludlage, E. ; Murphy, C. L. ; Davern, S. M. ; Solomon, Alan ; Weiss, D. T. ; Glenn-Smith, D. ; Dworkin, S. ; Mansfield, K. G. / Systemic AA amyloidosis in the common marmoset. In: Veterinary Pathology. 2005 ; Vol. 42, No. 2. pp. 117-124.
@article{0aec77bf21e5408e915394a4617a474c,
title = "Systemic AA amyloidosis in the common marmoset",
abstract = "The common marmoset (Callithrix jacchus) is a small New World primate native to Brazil that has been used extensively in biomedical research. A retrospective analysis of archived hematoxylin and eosinstained tissue sections and clinical records was conducted at the New England Primate Research Center on 86 marmosets more than 1 year of age that were euthanized during the past decade because of morbidity and failure to thrive. Approximately 17{\%} (15 of 86) were found to have amyloid deposits in one or more organs, including the liver, adrenal glands, kidneys, and intestine. This material was shown by amino acid sequence analysis to be composed of serum amyloid A (SAA)-related protein. This type of amyloidosis, designated AA or {"}secondary,{"} is associated typically with an inflammatory process that induces elevated levels of the SAA amyloidogenic precursor molecule. Notably, there were no significant pathologic differences or other distinguishing features in animals with amyloid versus those without; furthermore, on the basis of the limited number of serum specimens available for analysis, the SAA concentrations in the two groups were comparable, thus suggesting the possible inheritable nature of the disorder. In this respect, the common marmoset provides a unique experimental model for study of the pathogenesis and treatment of AA and other forms of systemic amyloidosis.",
author = "E. Ludlage and Murphy, {C. L.} and Davern, {S. M.} and Alan Solomon and Weiss, {D. T.} and D. Glenn-Smith and S. Dworkin and Mansfield, {K. G.}",
year = "2005",
month = "3",
day = "1",
doi = "10.1354/vp.42-2-117",
language = "English (US)",
volume = "42",
pages = "117--124",
journal = "Veterinary Pathology",
issn = "0300-9858",
publisher = "SAGE Publications Ltd",
number = "2",

}

TY - JOUR

T1 - Systemic AA amyloidosis in the common marmoset

AU - Ludlage, E.

AU - Murphy, C. L.

AU - Davern, S. M.

AU - Solomon, Alan

AU - Weiss, D. T.

AU - Glenn-Smith, D.

AU - Dworkin, S.

AU - Mansfield, K. G.

PY - 2005/3/1

Y1 - 2005/3/1

N2 - The common marmoset (Callithrix jacchus) is a small New World primate native to Brazil that has been used extensively in biomedical research. A retrospective analysis of archived hematoxylin and eosinstained tissue sections and clinical records was conducted at the New England Primate Research Center on 86 marmosets more than 1 year of age that were euthanized during the past decade because of morbidity and failure to thrive. Approximately 17% (15 of 86) were found to have amyloid deposits in one or more organs, including the liver, adrenal glands, kidneys, and intestine. This material was shown by amino acid sequence analysis to be composed of serum amyloid A (SAA)-related protein. This type of amyloidosis, designated AA or "secondary," is associated typically with an inflammatory process that induces elevated levels of the SAA amyloidogenic precursor molecule. Notably, there were no significant pathologic differences or other distinguishing features in animals with amyloid versus those without; furthermore, on the basis of the limited number of serum specimens available for analysis, the SAA concentrations in the two groups were comparable, thus suggesting the possible inheritable nature of the disorder. In this respect, the common marmoset provides a unique experimental model for study of the pathogenesis and treatment of AA and other forms of systemic amyloidosis.

AB - The common marmoset (Callithrix jacchus) is a small New World primate native to Brazil that has been used extensively in biomedical research. A retrospective analysis of archived hematoxylin and eosinstained tissue sections and clinical records was conducted at the New England Primate Research Center on 86 marmosets more than 1 year of age that were euthanized during the past decade because of morbidity and failure to thrive. Approximately 17% (15 of 86) were found to have amyloid deposits in one or more organs, including the liver, adrenal glands, kidneys, and intestine. This material was shown by amino acid sequence analysis to be composed of serum amyloid A (SAA)-related protein. This type of amyloidosis, designated AA or "secondary," is associated typically with an inflammatory process that induces elevated levels of the SAA amyloidogenic precursor molecule. Notably, there were no significant pathologic differences or other distinguishing features in animals with amyloid versus those without; furthermore, on the basis of the limited number of serum specimens available for analysis, the SAA concentrations in the two groups were comparable, thus suggesting the possible inheritable nature of the disorder. In this respect, the common marmoset provides a unique experimental model for study of the pathogenesis and treatment of AA and other forms of systemic amyloidosis.

UR - http://www.scopus.com/inward/record.url?scp=20144367311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20144367311&partnerID=8YFLogxK

U2 - 10.1354/vp.42-2-117

DO - 10.1354/vp.42-2-117

M3 - Article

VL - 42

SP - 117

EP - 124

JO - Veterinary Pathology

JF - Veterinary Pathology

SN - 0300-9858

IS - 2

ER -