Systemic lupus erythematosus associated with type 4 renal tubular acidosis: A case report and review of the literature

Haldane Porteous, Nadia Morgan, Julio Lanfranco Molina, Monica Garcia-Buitrago, Larry Young, Oliver Lenz

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Introduction. Type 4 renal tubular acidosis is an uncommon clinical manifestation of systemic lupus erythematosus and has been reported to portend a poor prognosis. To the best of our knowledge, this is the first case report which highlights the successful management of a patient with systemic lupus erythematosus complicated by type 4 renal tubular acidosis who did not do poorly. Case presentation. A 44-year-old Hispanic woman developed a non-anion gap hyperkalemic metabolic acidosis consistent with type 4 renal tubular acidosis while being treated in the hospital for recently diagnosed systemic lupus erythematosus with multi-organ involvement. She responded well to treatment with corticosteroids, hydroxychloroquine and mycophenolate mofetil. Normal renal function was achieved prior to discharge and remained normal at the patient's one-month follow-up examination. Conclusion: This case increases awareness of an uncommon association between systemic lupus erythematosus and type 4 renal tubular acidosis and suggests a positive impact of early diagnosis and appropriate immunosuppressive treatment on the patient's outcome.

Original languageEnglish (US)
Article number114
JournalJournal of Medical Case Reports
Volume5
DOIs
StatePublished - Mar 31 2011
Externally publishedYes

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Hypoaldosteronism
Systemic Lupus Erythematosus
Mycophenolic Acid
Hydroxychloroquine
Immunosuppressive Agents
Acidosis
Hispanic Americans
Early Diagnosis
Adrenal Cortex Hormones
Kidney
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Systemic lupus erythematosus associated with type 4 renal tubular acidosis : A case report and review of the literature. / Porteous, Haldane; Morgan, Nadia; Lanfranco Molina, Julio; Garcia-Buitrago, Monica; Young, Larry; Lenz, Oliver.

In: Journal of Medical Case Reports, Vol. 5, 114, 31.03.2011.

Research output: Contribution to journalReview article

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AU - Morgan, Nadia

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AU - Young, Larry

AU - Lenz, Oliver

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N2 - Introduction. Type 4 renal tubular acidosis is an uncommon clinical manifestation of systemic lupus erythematosus and has been reported to portend a poor prognosis. To the best of our knowledge, this is the first case report which highlights the successful management of a patient with systemic lupus erythematosus complicated by type 4 renal tubular acidosis who did not do poorly. Case presentation. A 44-year-old Hispanic woman developed a non-anion gap hyperkalemic metabolic acidosis consistent with type 4 renal tubular acidosis while being treated in the hospital for recently diagnosed systemic lupus erythematosus with multi-organ involvement. She responded well to treatment with corticosteroids, hydroxychloroquine and mycophenolate mofetil. Normal renal function was achieved prior to discharge and remained normal at the patient's one-month follow-up examination. Conclusion: This case increases awareness of an uncommon association between systemic lupus erythematosus and type 4 renal tubular acidosis and suggests a positive impact of early diagnosis and appropriate immunosuppressive treatment on the patient's outcome.

AB - Introduction. Type 4 renal tubular acidosis is an uncommon clinical manifestation of systemic lupus erythematosus and has been reported to portend a poor prognosis. To the best of our knowledge, this is the first case report which highlights the successful management of a patient with systemic lupus erythematosus complicated by type 4 renal tubular acidosis who did not do poorly. Case presentation. A 44-year-old Hispanic woman developed a non-anion gap hyperkalemic metabolic acidosis consistent with type 4 renal tubular acidosis while being treated in the hospital for recently diagnosed systemic lupus erythematosus with multi-organ involvement. She responded well to treatment with corticosteroids, hydroxychloroquine and mycophenolate mofetil. Normal renal function was achieved prior to discharge and remained normal at the patient's one-month follow-up examination. Conclusion: This case increases awareness of an uncommon association between systemic lupus erythematosus and type 4 renal tubular acidosis and suggests a positive impact of early diagnosis and appropriate immunosuppressive treatment on the patient's outcome.

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