Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice

A. Delprato, B. Bonheur, M. P. Algéo, P. Rosay, Lu Lu, Robert Williams, W. E. Crusio

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Variation in hippocampal neuroanatomy correlates well with spatial learning ability in mice. Here, we have studied both hippocampal neuroanatomy and behavior in 53 isogenic BXD recombinant strains derived from C57BL/6J and DBA/2J parents. A combination of experimental, neuroinformatic and systems genetics methods was used to test the genetic bases of variation and covariation among traits. Data were collected on seven hippocampal subregions in CA3 and CA4 after testing spatial memory in an eight-arm radial maze task. Quantitative trait loci were identified for hippocampal structure, including the areas of the intra- and infrapyramidal mossy fibers (IIPMFs), stratum radiatum and stratum pyramidale, and for a spatial learning parameter, error rate. We identified multiple loci and gene variants linked to either structural differences or behavior. Gpc4 and Tenm2 are strong candidate genes that may modulate IIPMF areas. Analysis of gene expression networks and trait correlations highlight several processes influencing morphometrical variation and spatial learning.

Original languageEnglish (US)
Pages (from-to)591-606
Number of pages16
JournalGenes, Brain and Behavior
Volume14
Issue number8
DOIs
StatePublished - Nov 1 2015

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Neuroanatomy
Gene Regulatory Networks
Quantitative Trait Loci
Genes
Gene Expression
Spatial Learning

All Science Journal Classification (ASJC) codes

  • Genetics
  • Neurology
  • Behavioral Neuroscience

Cite this

Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. / Delprato, A.; Bonheur, B.; Algéo, M. P.; Rosay, P.; Lu, Lu; Williams, Robert; Crusio, W. E.

In: Genes, Brain and Behavior, Vol. 14, No. 8, 01.11.2015, p. 591-606.

Research output: Contribution to journalArticle

Delprato, A. ; Bonheur, B. ; Algéo, M. P. ; Rosay, P. ; Lu, Lu ; Williams, Robert ; Crusio, W. E. / Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. In: Genes, Brain and Behavior. 2015 ; Vol. 14, No. 8. pp. 591-606.
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