Systems genetics analysis of molecular pathways underlying ethanol-induced behavioral phenotypes

Jesse D. Ziebarth, Melloni N. Cook, Biao Li, Robert Williams, Lu Lu, Yan Cui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Acute behavioral responses to alcohol have been shown to be contributing factors to alcoholism, a disease that may be associated with high stress levels and brain injury. In this study, the LXS line of recombinant inbred mouse strains is used to develop understanding of the genetic basis of ethanol response, by finding links between genotype, gene expression data, and phenotypes associated with increased locomotor activity in mice treated with ethanol. The results of quantitative trait locus (QTL) mapping for phenotypes and gene expression data for LXS mice treated with alcohol are compared with a control group. A method in which Bayesian network modeling is used to discover casual pathways from genotype to gene expression to phenotype is also presented.

Original languageEnglish (US)
Title of host publicationProceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010
Subtitle of host publicationBiomedical Research and Analysis in Neuroscience, BRAiN
DOIs
StatePublished - Aug 20 2010
Externally publishedYes
Event2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN - Oak Ridge, TN, United States
Duration: May 25 2010May 26 2010

Other

Other2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN
CountryUnited States
CityOak Ridge, TN
Period5/25/105/26/10

Fingerprint

Gene expression
Ethanol
Alcohols
Bayesian networks
Brain
Genetics

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Ziebarth, J. D., Cook, M. N., Li, B., Williams, R., Lu, L., & Cui, Y. (2010). Systems genetics analysis of molecular pathways underlying ethanol-induced behavioral phenotypes. In Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN [5510821] https://doi.org/10.1109/BSEC.2010.5510821

Systems genetics analysis of molecular pathways underlying ethanol-induced behavioral phenotypes. / Ziebarth, Jesse D.; Cook, Melloni N.; Li, Biao; Williams, Robert; Lu, Lu; Cui, Yan.

Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN. 2010. 5510821.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ziebarth, JD, Cook, MN, Li, B, Williams, R, Lu, L & Cui, Y 2010, Systems genetics analysis of molecular pathways underlying ethanol-induced behavioral phenotypes. in Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN., 5510821, 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN, Oak Ridge, TN, United States, 5/25/10. https://doi.org/10.1109/BSEC.2010.5510821
Ziebarth JD, Cook MN, Li B, Williams R, Lu L, Cui Y. Systems genetics analysis of molecular pathways underlying ethanol-induced behavioral phenotypes. In Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN. 2010. 5510821 https://doi.org/10.1109/BSEC.2010.5510821
Ziebarth, Jesse D. ; Cook, Melloni N. ; Li, Biao ; Williams, Robert ; Lu, Lu ; Cui, Yan. / Systems genetics analysis of molecular pathways underlying ethanol-induced behavioral phenotypes. Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN. 2010.
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