Systems genetics can provide new insights in to immune regulation and autoimmunity

Grant Morahan, Violet Peeva, Munish Mehta, Robert Williams

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

"Systems Genetics" detects variation in phenotypic traits and integrates this with underlying genetic variation. A powerful application of systems genetics is analyzing effects of genome-wide genetic variants on transcriptome-wide variation in gene expression. We see systems genetics as a new powerful technology which will empower research in genetics and in other disciplines. Here, we present preliminary analyses of systems genetics approaches to defining genetic interactions within the thymus, which is the key site for T lymphocyte development and imposition of immunological tolerance.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalJournal of Autoimmunity
Volume31
Issue number3
DOIs
StatePublished - Nov 1 2008

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Autoimmunity
Genetic Research
Systems Analysis
Transcriptome
Thymus Gland
Genome
Technology
T-Lymphocytes
Gene Expression

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Systems genetics can provide new insights in to immune regulation and autoimmunity. / Morahan, Grant; Peeva, Violet; Mehta, Munish; Williams, Robert.

In: Journal of Autoimmunity, Vol. 31, No. 3, 01.11.2008, p. 233-236.

Research output: Contribution to journalArticle

Morahan, Grant ; Peeva, Violet ; Mehta, Munish ; Williams, Robert. / Systems genetics can provide new insights in to immune regulation and autoimmunity. In: Journal of Autoimmunity. 2008 ; Vol. 31, No. 3. pp. 233-236.
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