Systems genetics of behavior

A prelude

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Behaviors are among the most complex phenotypes - the end product of intertwined networks of genetic, molecular, cellular, physiological, environmental, and social factors. While reductionist methods that test contributions of single genes are crucial to define components of behavior, there are now complementary integrative methods that can model and predict behavior in a more global context. Systems genetics is a new field that exploits massive multiscalar data to study patterns of covariation in complex biological systems. As applied to behavioral genetics, this field looks inside the black box to understand hierarchies of molecular and cellular traits and connections that link gene variants and environment to behavior. Here we explore recent progress and challenges in this new field.

Original languageEnglish (US)
Pages (from-to)108-115
Number of pages8
JournalCurrent Opinion in Behavioral Sciences
Volume2
DOIs
StatePublished - Apr 1 2015

Fingerprint

Behavioral Genetics
Genes
Molecular Biology
Phenotype

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Systems genetics of behavior : A prelude. / Mulligan, Megan; Williams, Robert.

In: Current Opinion in Behavioral Sciences, Vol. 2, 01.04.2015, p. 108-115.

Research output: Contribution to journalReview article

@article{807c4b971a58467bb874af60b547e568,
title = "Systems genetics of behavior: A prelude",
abstract = "Behaviors are among the most complex phenotypes - the end product of intertwined networks of genetic, molecular, cellular, physiological, environmental, and social factors. While reductionist methods that test contributions of single genes are crucial to define components of behavior, there are now complementary integrative methods that can model and predict behavior in a more global context. Systems genetics is a new field that exploits massive multiscalar data to study patterns of covariation in complex biological systems. As applied to behavioral genetics, this field looks inside the black box to understand hierarchies of molecular and cellular traits and connections that link gene variants and environment to behavior. Here we explore recent progress and challenges in this new field.",
author = "Megan Mulligan and Robert Williams",
year = "2015",
month = "4",
day = "1",
doi = "10.1016/j.cobeha.2015.01.014",
language = "English (US)",
volume = "2",
pages = "108--115",
journal = "Current Opinion in Behavioral Sciences",
issn = "2352-1546",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Systems genetics of behavior

T2 - A prelude

AU - Mulligan, Megan

AU - Williams, Robert

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Behaviors are among the most complex phenotypes - the end product of intertwined networks of genetic, molecular, cellular, physiological, environmental, and social factors. While reductionist methods that test contributions of single genes are crucial to define components of behavior, there are now complementary integrative methods that can model and predict behavior in a more global context. Systems genetics is a new field that exploits massive multiscalar data to study patterns of covariation in complex biological systems. As applied to behavioral genetics, this field looks inside the black box to understand hierarchies of molecular and cellular traits and connections that link gene variants and environment to behavior. Here we explore recent progress and challenges in this new field.

AB - Behaviors are among the most complex phenotypes - the end product of intertwined networks of genetic, molecular, cellular, physiological, environmental, and social factors. While reductionist methods that test contributions of single genes are crucial to define components of behavior, there are now complementary integrative methods that can model and predict behavior in a more global context. Systems genetics is a new field that exploits massive multiscalar data to study patterns of covariation in complex biological systems. As applied to behavioral genetics, this field looks inside the black box to understand hierarchies of molecular and cellular traits and connections that link gene variants and environment to behavior. Here we explore recent progress and challenges in this new field.

UR - http://www.scopus.com/inward/record.url?scp=84922983098&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922983098&partnerID=8YFLogxK

U2 - 10.1016/j.cobeha.2015.01.014

DO - 10.1016/j.cobeha.2015.01.014

M3 - Review article

VL - 2

SP - 108

EP - 115

JO - Current Opinion in Behavioral Sciences

JF - Current Opinion in Behavioral Sciences

SN - 2352-1546

ER -