Target recognition and visual maps in the thalamus of achiasmatic dogs

Robert Williams, Dale Hogan, Preston E. Garraghty

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

VISION is dependent on ordered neuronal representations or maps of visual space. These maps depend on precise connections between retinal axons and their targets cells. In mammals, nerve fibres from right and left eyes produce congruent maps of contralateral visual space in adjacent layers of the lateral geniculate nucleus (LGN)1. We have identified an autosomal recessive mutation in Belgian sheepdogs2,3 that eliminates the optic chiasm. In these mutants, all retinal axons project into the ipsilateral optic tract, including those originating in the nasal hemiretina that normally cross midline. These animals exhibit a pronounced horizontal nystagmus4,5. The abnormal ipsilaterally directed nasal fibres innervate the LGN as if they had successfully crossed the midline, terminating in the appropriate layer of the nucleus. As a consequence, the LGN contains non-congruent, mirror-image maps of visual space in adjacent layers. These results show that there is a robust affinity between nasal and temporal retinal axons and specific LGN layers even when all retinal axons originate from a single eye.

Original languageEnglish (US)
Pages (from-to)637-639
Number of pages3
JournalNature
Volume367
Issue number6464
DOIs
StatePublished - Jan 1 1994

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Geniculate Bodies
Thalamus
Axons
Nose
Dogs
Optic Chiasm
Nerve Fibers
Mammals
Mutation

All Science Journal Classification (ASJC) codes

  • General

Cite this

Target recognition and visual maps in the thalamus of achiasmatic dogs. / Williams, Robert; Hogan, Dale; Garraghty, Preston E.

In: Nature, Vol. 367, No. 6464, 01.01.1994, p. 637-639.

Research output: Contribution to journalArticle

Williams, Robert ; Hogan, Dale ; Garraghty, Preston E. / Target recognition and visual maps in the thalamus of achiasmatic dogs. In: Nature. 1994 ; Vol. 367, No. 6464. pp. 637-639.
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