Targeting chemophotothermal therapy of hepatoma by gold nanorods/graphene oxide core/shell nanocomposites

Cheng Xu, Darong Yang, Lin Mei, Qiuhong Li, Haizhen Zhu, Taihong Wang

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Nanographene oxide (NGO) are highly suitable to be the shells of inorganic nanomaterials to enhance their biocompatibility and hydrophilicity for biomedical applications while retaining their useful photonic, magnetic, or radiological functions. In this study, a novel nanostructure with gold nanorods (AuNRs) encapsulated in NGO shells is developed to be an ultraefficient chemophotothermal cancer therapy agent. The NGO shells decrease the toxicity of surfactant-coated AuNRs and provide anchor points for the conjugation of hyaluronic acid (HA). The HA-conjugated NGO-enwrapped AuNR nanocomposites (NGOHA-AuNRs) perform higher photothermal efficiency than AuNRs and have the capability of targeting hepatoma Huh-7 cells. NGOHA-AuNR is applied to load doxorubicin (DOX), and it exhibits pH-responsive and near-infrared light-triggered drug-release properties. Chemophotothermal combined therapy by NGOHA-AuNRs-DOX performs 1.5-fold and 4-fold higher targeting cell death rates than single chemotherapy and photothermal therapy, respectively, with biosafety to nontargeting cells simultaneously. Furthermore, our strategy could be extended to constructing other NGO-encapsulated functional nanomaterial-based carrier systems.

Original languageEnglish (US)
Pages (from-to)12911-12920
Number of pages10
JournalACS Applied Materials and Interfaces
Volume5
Issue number24
DOIs
StatePublished - Dec 26 2013

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Nanocomposites
Nanotubes
Graphite
Nanorods
Gold
Oxides
Graphene
Hepatocellular Carcinoma
Nanostructures
Hyaluronic acid
Hyaluronic Acid
Nanostructured materials
Doxorubicin
Optics and Photonics
Therapeutics
Chemotherapy
Hydrophilicity
Cell death
Anchors
Hydrophobic and Hydrophilic Interactions

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Targeting chemophotothermal therapy of hepatoma by gold nanorods/graphene oxide core/shell nanocomposites. / Xu, Cheng; Yang, Darong; Mei, Lin; Li, Qiuhong; Zhu, Haizhen; Wang, Taihong.

In: ACS Applied Materials and Interfaces, Vol. 5, No. 24, 26.12.2013, p. 12911-12920.

Research output: Contribution to journalArticle

Xu, Cheng ; Yang, Darong ; Mei, Lin ; Li, Qiuhong ; Zhu, Haizhen ; Wang, Taihong. / Targeting chemophotothermal therapy of hepatoma by gold nanorods/graphene oxide core/shell nanocomposites. In: ACS Applied Materials and Interfaces. 2013 ; Vol. 5, No. 24. pp. 12911-12920.
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