Targeting TRPM8 for pain relief

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel activated by cold temperature and cooling agents. TRPM8 is expressed in peripheral cold thermoreceptors and plays a fundamental role in sensing mild, cool temperatures. In addition, cumulative evidence obtained in humans and different animals models, combined with pharmacological and gene silencing techniques, suggest that TRPM8 may also play a role in cold discomfort and the pathophysiology of cold pain. This article reviews the available evidence in a critical fashion. In addition, the article reviews the possible role of TRPM8 in basal tearing, cold urticaria and airway irritation. Collectively, these results suggest that pharmacological modulators of TRPM8 could have potential indications in a variety of conditions, including dry eye disease, airway irritation, teeth hypersensitivity, migraine and neuropathic pain. However, additional studies, especially in humans, are needed to verify these preliminary observations. The paucity of potent, specific pharmacological TRPM8 antagonists available is a current limitation for further progress in this field.

Original languageEnglish (US)
Pages (from-to)154-164
Number of pages11
JournalOpen Pain Journal
Volume6
Issue numberSPEC.ISSUE.1
DOIs
StatePublished - Apr 18 2013

Fingerprint

Pain
Pharmacology
Thermoreceptors
Eye Diseases
Urticaria
Neuralgia
Gene Silencing
Migraine Disorders
Cations
Tooth
Hypersensitivity
Animal Models
Temperature

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

Targeting TRPM8 for pain relief. / Fernandez Pena Acuna, Carlos; Viana, Felix.

In: Open Pain Journal, Vol. 6, No. SPEC.ISSUE.1, 18.04.2013, p. 154-164.

Research output: Contribution to journalReview article

Fernandez Pena Acuna, Carlos ; Viana, Felix. / Targeting TRPM8 for pain relief. In: Open Pain Journal. 2013 ; Vol. 6, No. SPEC.ISSUE.1. pp. 154-164.
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