Taurine regulation of voltage-gated channels in retinal neurons

Matthew J.M. Rowan, Simon Bulley, Lauren A. Purpura, Harris Ripps, Wen Shen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Taurine activates not only Cl -permeable ionotropic receptors but also receptors that mediate metabotropic responses. The metabotropic property of taurine was revealed in electrophysiological recordings obtained after fully blocking Cl -permeable receptors with an inhibitory "cocktail" consisting of picrotoxin, SR95531, and strychnine. We found that taurine's metabotropic effects regulate voltage-gated channels in retinal neurons. After applying the inhibitory cocktail, taurine enhanced delayed outward rectifier K + channels preferentially in Offbipolar cells, and the effect was completely blocked by the specific PKC inhibitor, GF109203X. Additionally, taurine also acted through a metabotropic pathway to suppress both L- and N-type Ca 2+ channels in retinal neurons, which were insensitive to the potent GABA B receptor inhibitor, CGP55845. This study reinforces our previous finding that taurine in physiological concentrations produces a multiplicity of metabotropic effects that precisely govern the integration of signals being transmitted from the retina to the brain.

Original languageEnglish (US)
Title of host publicationTaurine 8
Subtitle of host publicationVolume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System
PublisherSpringer New York LLC
Pages85-99
Number of pages15
ISBN (Print)9781461461296
DOIs
StatePublished - Jan 1 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume775
ISSN (Print)0065-2598

Fingerprint

Retinal Neurons
Taurine
Neurons
Electric potential
GABA-B Receptors
Strychnine
Picrotoxin
Retina
Brain

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rowan, M. J. M., Bulley, S., Purpura, L. A., Ripps, H., & Shen, W. (2013). Taurine regulation of voltage-gated channels in retinal neurons. In Taurine 8: Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System (pp. 85-99). (Advances in Experimental Medicine and Biology; Vol. 775). Springer New York LLC. https://doi.org/10.1007/978-1-4614-6130-2_7

Taurine regulation of voltage-gated channels in retinal neurons. / Rowan, Matthew J.M.; Bulley, Simon; Purpura, Lauren A.; Ripps, Harris; Shen, Wen.

Taurine 8: Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System. Springer New York LLC, 2013. p. 85-99 (Advances in Experimental Medicine and Biology; Vol. 775).

Research output: Chapter in Book/Report/Conference proceedingChapter

Rowan, MJM, Bulley, S, Purpura, LA, Ripps, H & Shen, W 2013, Taurine regulation of voltage-gated channels in retinal neurons. in Taurine 8: Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System. Advances in Experimental Medicine and Biology, vol. 775, Springer New York LLC, pp. 85-99. https://doi.org/10.1007/978-1-4614-6130-2_7
Rowan MJM, Bulley S, Purpura LA, Ripps H, Shen W. Taurine regulation of voltage-gated channels in retinal neurons. In Taurine 8: Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System. Springer New York LLC. 2013. p. 85-99. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-6130-2_7
Rowan, Matthew J.M. ; Bulley, Simon ; Purpura, Lauren A. ; Ripps, Harris ; Shen, Wen. / Taurine regulation of voltage-gated channels in retinal neurons. Taurine 8: Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System. Springer New York LLC, 2013. pp. 85-99 (Advances in Experimental Medicine and Biology).
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