Telomere length as an indicator of the robustness of B- and T-cell response to influenza in older adults

Kevin Najarro, Huy Nguyen, Guobing Chen, Mai Xu, Sandy Alcorta, Xu Yao, Linda Zukley, E. Metter, Thai Truong, Yun Lin, Huifen Li, Mathias Oelke, Xiyan Xu, Shari M. Ling, Dan L. Longo, Jonathan Schneck, Sean Leng, Luigi Ferrucci, Nan Ping Weng

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Abstract

Background.Telomeres provide a key mechanism for protecting the integrity of chromosomes and their attrition after cell division and during aging are evident in lymphocytes. However, the significance of telomere shortening in age-associated decline of immune function is unknown. Methods.We selected 22 HLA-A2-positive healthy older adults who have relatively short or long telomere lengths to compare their antibody response against the influenza vaccine, and their CD8+ T-cell response against an influenza antigen. Results.B cells from individuals with a robust antibody response to the influenza vaccine had significantly longer telomeres than those with a poor antibody response. Monocyte-derived antigen-presenting cells of both short and long telomere groups induced similar expansions of influenza M1-specific CD8+ T cells. Vaccination did not increase M1-specific CD8+ T cells in blood, but M1-specific CD8+ T cells from the long telomere group exhibited significantly greater expansion in vitro than those from the short telomere group. Finally, M1-specific CD8+ T cells that underwent more expansions had significantly longer telomeres than cells with fewer divisions. Conclusions.Telomere length is positively associated with a robust lymphocyte response, and telomere attrition may contribute to the age-associated decline of adaptive immunity.

Original languageEnglish (US)
Pages (from-to)1261-1269
Number of pages9
JournalJournal of Infectious Diseases
Volume212
Issue number8
DOIs
StatePublished - Oct 15 2015

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Telomere
Human Influenza
T-Lymphocytes
Antibody Formation
Influenza Vaccines
Lymphocytes
Telomere Shortening
HLA-A2 Antigen
Adaptive Immunity
Antigen-Presenting Cells
Cell Division
Monocytes
Vaccination
B-Lymphocytes
Chromosomes
Antigens

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Telomere length as an indicator of the robustness of B- and T-cell response to influenza in older adults. / Najarro, Kevin; Nguyen, Huy; Chen, Guobing; Xu, Mai; Alcorta, Sandy; Yao, Xu; Zukley, Linda; Metter, E.; Truong, Thai; Lin, Yun; Li, Huifen; Oelke, Mathias; Xu, Xiyan; Ling, Shari M.; Longo, Dan L.; Schneck, Jonathan; Leng, Sean; Ferrucci, Luigi; Weng, Nan Ping.

In: Journal of Infectious Diseases, Vol. 212, No. 8, 15.10.2015, p. 1261-1269.

Research output: Contribution to journalArticle

Najarro, K, Nguyen, H, Chen, G, Xu, M, Alcorta, S, Yao, X, Zukley, L, Metter, E, Truong, T, Lin, Y, Li, H, Oelke, M, Xu, X, Ling, SM, Longo, DL, Schneck, J, Leng, S, Ferrucci, L & Weng, NP 2015, 'Telomere length as an indicator of the robustness of B- and T-cell response to influenza in older adults', Journal of Infectious Diseases, vol. 212, no. 8, pp. 1261-1269. https://doi.org/10.1093/infdis/jiv202
Najarro, Kevin ; Nguyen, Huy ; Chen, Guobing ; Xu, Mai ; Alcorta, Sandy ; Yao, Xu ; Zukley, Linda ; Metter, E. ; Truong, Thai ; Lin, Yun ; Li, Huifen ; Oelke, Mathias ; Xu, Xiyan ; Ling, Shari M. ; Longo, Dan L. ; Schneck, Jonathan ; Leng, Sean ; Ferrucci, Luigi ; Weng, Nan Ping. / Telomere length as an indicator of the robustness of B- and T-cell response to influenza in older adults. In: Journal of Infectious Diseases. 2015 ; Vol. 212, No. 8. pp. 1261-1269.
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abstract = "Background.Telomeres provide a key mechanism for protecting the integrity of chromosomes and their attrition after cell division and during aging are evident in lymphocytes. However, the significance of telomere shortening in age-associated decline of immune function is unknown. Methods.We selected 22 HLA-A2-positive healthy older adults who have relatively short or long telomere lengths to compare their antibody response against the influenza vaccine, and their CD8+ T-cell response against an influenza antigen. Results.B cells from individuals with a robust antibody response to the influenza vaccine had significantly longer telomeres than those with a poor antibody response. Monocyte-derived antigen-presenting cells of both short and long telomere groups induced similar expansions of influenza M1-specific CD8+ T cells. Vaccination did not increase M1-specific CD8+ T cells in blood, but M1-specific CD8+ T cells from the long telomere group exhibited significantly greater expansion in vitro than those from the short telomere group. Finally, M1-specific CD8+ T cells that underwent more expansions had significantly longer telomeres than cells with fewer divisions. Conclusions.Telomere length is positively associated with a robust lymphocyte response, and telomere attrition may contribute to the age-associated decline of adaptive immunity.",
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T1 - Telomere length as an indicator of the robustness of B- and T-cell response to influenza in older adults

AU - Najarro, Kevin

AU - Nguyen, Huy

AU - Chen, Guobing

AU - Xu, Mai

AU - Alcorta, Sandy

AU - Yao, Xu

AU - Zukley, Linda

AU - Metter, E.

AU - Truong, Thai

AU - Lin, Yun

AU - Li, Huifen

AU - Oelke, Mathias

AU - Xu, Xiyan

AU - Ling, Shari M.

AU - Longo, Dan L.

AU - Schneck, Jonathan

AU - Leng, Sean

AU - Ferrucci, Luigi

AU - Weng, Nan Ping

PY - 2015/10/15

Y1 - 2015/10/15

N2 - Background.Telomeres provide a key mechanism for protecting the integrity of chromosomes and their attrition after cell division and during aging are evident in lymphocytes. However, the significance of telomere shortening in age-associated decline of immune function is unknown. Methods.We selected 22 HLA-A2-positive healthy older adults who have relatively short or long telomere lengths to compare their antibody response against the influenza vaccine, and their CD8+ T-cell response against an influenza antigen. Results.B cells from individuals with a robust antibody response to the influenza vaccine had significantly longer telomeres than those with a poor antibody response. Monocyte-derived antigen-presenting cells of both short and long telomere groups induced similar expansions of influenza M1-specific CD8+ T cells. Vaccination did not increase M1-specific CD8+ T cells in blood, but M1-specific CD8+ T cells from the long telomere group exhibited significantly greater expansion in vitro than those from the short telomere group. Finally, M1-specific CD8+ T cells that underwent more expansions had significantly longer telomeres than cells with fewer divisions. Conclusions.Telomere length is positively associated with a robust lymphocyte response, and telomere attrition may contribute to the age-associated decline of adaptive immunity.

AB - Background.Telomeres provide a key mechanism for protecting the integrity of chromosomes and their attrition after cell division and during aging are evident in lymphocytes. However, the significance of telomere shortening in age-associated decline of immune function is unknown. Methods.We selected 22 HLA-A2-positive healthy older adults who have relatively short or long telomere lengths to compare their antibody response against the influenza vaccine, and their CD8+ T-cell response against an influenza antigen. Results.B cells from individuals with a robust antibody response to the influenza vaccine had significantly longer telomeres than those with a poor antibody response. Monocyte-derived antigen-presenting cells of both short and long telomere groups induced similar expansions of influenza M1-specific CD8+ T cells. Vaccination did not increase M1-specific CD8+ T cells in blood, but M1-specific CD8+ T cells from the long telomere group exhibited significantly greater expansion in vitro than those from the short telomere group. Finally, M1-specific CD8+ T cells that underwent more expansions had significantly longer telomeres than cells with fewer divisions. Conclusions.Telomere length is positively associated with a robust lymphocyte response, and telomere attrition may contribute to the age-associated decline of adaptive immunity.

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