Test-retest reliability in an fMRI study of naming in dementia

Eun Jin Paek, Laura L. Murray, Sharlene D. Newman, Dae Jin Kim

Research output: Contribution to journalArticle

Abstract

fMRI has been used as an outcome measure in dementia treatment studies, with many previous studies comparing only single pre- and post-treatment fMRI scans to determine treatment-induced neural changes, while utilizing single subject experimental designs. The purpose of the current study was to evaluate fMRI test-retest reliability in dementia patients and typical older adults using noun and verb confrontation naming to evaluate the validity of using a single pre/post-treatment scan comparison. Seven individuals with dementia and 9 control participants were tested three times over two months using the same fMRI procedures. Differences in individual and group level activation patterns were observed that varied across time. Additionally, the extent of variability fluctuated across individuals, groups, and the grammatical category of target words. Our findings suggested that one time fMRI scanning may inadequately represent an individual's typical brain activation pattern, particularly an individual with dementia. Thus, multiple imaging baselines are recommended.

Original languageEnglish (US)
Pages (from-to)31-45
Number of pages15
JournalBrain and Language
Volume191
DOIs
StatePublished - Apr 1 2019

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dementia
Reproducibility of Results
Dementia
Magnetic Resonance Imaging
activation
Therapeutics
Individuality
brain
Research Design
Group
Outcome Assessment (Health Care)
Naming
Functional Magnetic Resonance Imaging
Test-retest Reliability
Brain
time

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

Cite this

Test-retest reliability in an fMRI study of naming in dementia. / Paek, Eun Jin; Murray, Laura L.; Newman, Sharlene D.; Kim, Dae Jin.

In: Brain and Language, Vol. 191, 01.04.2019, p. 31-45.

Research output: Contribution to journalArticle

Paek, Eun Jin ; Murray, Laura L. ; Newman, Sharlene D. ; Kim, Dae Jin. / Test-retest reliability in an fMRI study of naming in dementia. In: Brain and Language. 2019 ; Vol. 191. pp. 31-45.
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