Testis biopsy findings in the spinal cord injured patient

Sean P. Elliott, Francisco Orejuela, Irvin H. Hirsch, Larry I. Lipshultz, Dolores J. Lamb, Edward Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: Azoospermia after electroejaculation in spinal cord injured men may be due to testicular failure or obstruction. These men can initiate pregnancy with assisted reproductive techniques, such as intracytoplasmic sperm injection, but only if sperm are present in the testis biopsy. We analyzed the histopathology of testis biopsies from spinal cord injured men and assessed whether patient factors were predictive of testis biopsy pathology. Materials and Methods: A total of 50 paraplegic men undergoing testis biopsy were divided into 2 groups based on normal or abnormal testis histopathology. Patient age, post-injury years, level of lesion, hormonal status and semen analysis results were compared. Results: Spermatogenesis was normal in 28 of the 50 patients. Hypospermatogenesis was exhibited in 15, maturation arrest at the spermatid stage in 6 and maturation arrest at the spermatocyte stage in 1 of the 22 abnormal cases. Nevertheless, mature sperm were identified in 43 of 50 biopsies (normal spermatogenesis and hypospermatogenesis). Men with normal spermatogenesis had better forward progression of sperm and a higher testosterone-to-luteinizing hormone ratio. Otherwise, there was no statistically significant correlation between study variables and testis biopsy results. No factors were predictive of testis biopsy histopathology. Conclusions: The documentation of mature sperm in 43 of 50 biopsies from spinal cord injured patients suggests that a high rate of sperm retrieval is possible using testicular sperm extraction if sperm cannot be retrieved from the ejaculate. With intracytoplasmic sperm injection techniques the majority of spinal cord injured men retain fertility potential, even if azoospermic following electroejaculation.

Original languageEnglish (US)
Pages (from-to)792-795
Number of pages4
JournalJournal of Urology
Volume163
Issue number3
DOIs
StatePublished - Jan 1 2000

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Testis
Spinal Cord
Biopsy
Spermatozoa
Spermatogenesis
Oligospermia
Intracytoplasmic Sperm Injections
Sperm Retrieval
Azoospermia
Assisted Reproductive Techniques
Spermatocytes
Semen Analysis
Spermatids
Luteinizing Hormone
Documentation
Fertility
Testosterone
Pathology
Pregnancy
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Elliott, S. P., Orejuela, F., Hirsch, I. H., Lipshultz, L. I., Lamb, D. J., & Kim, E. (2000). Testis biopsy findings in the spinal cord injured patient. Journal of Urology, 163(3), 792-795. https://doi.org/10.1016/S0022-5347(05)67806-8

Testis biopsy findings in the spinal cord injured patient. / Elliott, Sean P.; Orejuela, Francisco; Hirsch, Irvin H.; Lipshultz, Larry I.; Lamb, Dolores J.; Kim, Edward.

In: Journal of Urology, Vol. 163, No. 3, 01.01.2000, p. 792-795.

Research output: Contribution to journalArticle

Elliott, SP, Orejuela, F, Hirsch, IH, Lipshultz, LI, Lamb, DJ & Kim, E 2000, 'Testis biopsy findings in the spinal cord injured patient', Journal of Urology, vol. 163, no. 3, pp. 792-795. https://doi.org/10.1016/S0022-5347(05)67806-8
Elliott SP, Orejuela F, Hirsch IH, Lipshultz LI, Lamb DJ, Kim E. Testis biopsy findings in the spinal cord injured patient. Journal of Urology. 2000 Jan 1;163(3):792-795. https://doi.org/10.1016/S0022-5347(05)67806-8
Elliott, Sean P. ; Orejuela, Francisco ; Hirsch, Irvin H. ; Lipshultz, Larry I. ; Lamb, Dolores J. ; Kim, Edward. / Testis biopsy findings in the spinal cord injured patient. In: Journal of Urology. 2000 ; Vol. 163, No. 3. pp. 792-795.
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