The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease

Asad Vaisi-Raygani, Hori Ghaneialvar, Zohreh Rahimi, Hamid Nomani, Mohmadreza Saidi, Fariborz Bahrehmand, Aliakbar Vaisi-Raygani, Haidar Tavilani, Tayebeh Pourmotabbed

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Abstract

Objective: The role of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in early onset coronary artery disease age < 55 years (ECAD) is controversial. The aim of this study was to further evaluate the role of this ACE(I/D) gene polymorphism on the risk of premature CAD in patients from western Iran. Methods: The ACE(I/D) genotypes were detected by PCR-RFLP in 323 individuals undergoing their first coronary angiography. Patients were placed into two groups: ECAD and late onset CAD age < 55 years (LCAD). Results: We found a statistically significant association of the ACE D allele, as homozygous or ACE ID plus DD genotypes (ID. +. DD), only in the ECAD subjects OR=1.35, p=0.015, OR=3.27, p=0.014, and OR=2.8, p=0.013, respectively. In addition, there was a significant association after adjustment for the absence of history of diabetes, presence of normolipidemia and absence of history of blood pressure [OR 1.38, p=0.017 and 2.35, p=0.02]. Our results indicated that the ACE D allele is a risk factor for early onset of CAD even after correcting for conventional risk factors. The incidence of triple vessel disease was significantly higher in individuals carrying ACE(D/D) genotype in ECAD patients compared to those who carried ACE(I/I) genotype (OR 3.38; p=0.019; 57.5% vs. 42.5%; p=0.013). Conclusion: The presence of D allele of ACE can be important independent risk factor in the onset of CAD patients less than 55. years old in a west population of Iran. Larger collaborative studies are needed to confirm these results.

Original languageEnglish (US)
Pages (from-to)1189-1194
Number of pages6
JournalClinical Biochemistry
Volume43
Issue number15
DOIs
StatePublished - Oct 1 2010

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Peptidyl-Dipeptidase A
Coronary Artery Disease
Alleles
Computer aided design
Genotype
Insertional Mutagenesis
Gene Deletion
Iran
Polymorphism
Genes
Angiography
Blood pressure
Medical problems
Coronary Angiography
Age of Onset
Restriction Fragment Length Polymorphisms
Blood Pressure
Polymerase Chain Reaction
Incidence

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease. / Vaisi-Raygani, Asad; Ghaneialvar, Hori; Rahimi, Zohreh; Nomani, Hamid; Saidi, Mohmadreza; Bahrehmand, Fariborz; Vaisi-Raygani, Aliakbar; Tavilani, Haidar; Pourmotabbed, Tayebeh.

In: Clinical Biochemistry, Vol. 43, No. 15, 01.10.2010, p. 1189-1194.

Research output: Contribution to journalArticle

Vaisi-Raygani, A, Ghaneialvar, H, Rahimi, Z, Nomani, H, Saidi, M, Bahrehmand, F, Vaisi-Raygani, A, Tavilani, H & Pourmotabbed, T 2010, 'The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease', Clinical Biochemistry, vol. 43, no. 15, pp. 1189-1194. https://doi.org/10.1016/j.clinbiochem.2010.07.010
Vaisi-Raygani, Asad ; Ghaneialvar, Hori ; Rahimi, Zohreh ; Nomani, Hamid ; Saidi, Mohmadreza ; Bahrehmand, Fariborz ; Vaisi-Raygani, Aliakbar ; Tavilani, Haidar ; Pourmotabbed, Tayebeh. / The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease. In: Clinical Biochemistry. 2010 ; Vol. 43, No. 15. pp. 1189-1194.
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abstract = "Objective: The role of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in early onset coronary artery disease age < 55 years (ECAD) is controversial. The aim of this study was to further evaluate the role of this ACE(I/D) gene polymorphism on the risk of premature CAD in patients from western Iran. Methods: The ACE(I/D) genotypes were detected by PCR-RFLP in 323 individuals undergoing their first coronary angiography. Patients were placed into two groups: ECAD and late onset CAD age < 55 years (LCAD). Results: We found a statistically significant association of the ACE D allele, as homozygous or ACE ID plus DD genotypes (ID. +. DD), only in the ECAD subjects OR=1.35, p=0.015, OR=3.27, p=0.014, and OR=2.8, p=0.013, respectively. In addition, there was a significant association after adjustment for the absence of history of diabetes, presence of normolipidemia and absence of history of blood pressure [OR 1.38, p=0.017 and 2.35, p=0.02]. Our results indicated that the ACE D allele is a risk factor for early onset of CAD even after correcting for conventional risk factors. The incidence of triple vessel disease was significantly higher in individuals carrying ACE(D/D) genotype in ECAD patients compared to those who carried ACE(I/I) genotype (OR 3.38; p=0.019; 57.5{\%} vs. 42.5{\%}; p=0.013). Conclusion: The presence of D allele of ACE can be important independent risk factor in the onset of CAD patients less than 55. years old in a west population of Iran. Larger collaborative studies are needed to confirm these results.",
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AU - Vaisi-Raygani, Asad

AU - Ghaneialvar, Hori

AU - Rahimi, Zohreh

AU - Nomani, Hamid

AU - Saidi, Mohmadreza

AU - Bahrehmand, Fariborz

AU - Vaisi-Raygani, Aliakbar

AU - Tavilani, Haidar

AU - Pourmotabbed, Tayebeh

PY - 2010/10/1

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N2 - Objective: The role of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in early onset coronary artery disease age < 55 years (ECAD) is controversial. The aim of this study was to further evaluate the role of this ACE(I/D) gene polymorphism on the risk of premature CAD in patients from western Iran. Methods: The ACE(I/D) genotypes were detected by PCR-RFLP in 323 individuals undergoing their first coronary angiography. Patients were placed into two groups: ECAD and late onset CAD age < 55 years (LCAD). Results: We found a statistically significant association of the ACE D allele, as homozygous or ACE ID plus DD genotypes (ID. +. DD), only in the ECAD subjects OR=1.35, p=0.015, OR=3.27, p=0.014, and OR=2.8, p=0.013, respectively. In addition, there was a significant association after adjustment for the absence of history of diabetes, presence of normolipidemia and absence of history of blood pressure [OR 1.38, p=0.017 and 2.35, p=0.02]. Our results indicated that the ACE D allele is a risk factor for early onset of CAD even after correcting for conventional risk factors. The incidence of triple vessel disease was significantly higher in individuals carrying ACE(D/D) genotype in ECAD patients compared to those who carried ACE(I/I) genotype (OR 3.38; p=0.019; 57.5% vs. 42.5%; p=0.013). Conclusion: The presence of D allele of ACE can be important independent risk factor in the onset of CAD patients less than 55. years old in a west population of Iran. Larger collaborative studies are needed to confirm these results.

AB - Objective: The role of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in early onset coronary artery disease age < 55 years (ECAD) is controversial. The aim of this study was to further evaluate the role of this ACE(I/D) gene polymorphism on the risk of premature CAD in patients from western Iran. Methods: The ACE(I/D) genotypes were detected by PCR-RFLP in 323 individuals undergoing their first coronary angiography. Patients were placed into two groups: ECAD and late onset CAD age < 55 years (LCAD). Results: We found a statistically significant association of the ACE D allele, as homozygous or ACE ID plus DD genotypes (ID. +. DD), only in the ECAD subjects OR=1.35, p=0.015, OR=3.27, p=0.014, and OR=2.8, p=0.013, respectively. In addition, there was a significant association after adjustment for the absence of history of diabetes, presence of normolipidemia and absence of history of blood pressure [OR 1.38, p=0.017 and 2.35, p=0.02]. Our results indicated that the ACE D allele is a risk factor for early onset of CAD even after correcting for conventional risk factors. The incidence of triple vessel disease was significantly higher in individuals carrying ACE(D/D) genotype in ECAD patients compared to those who carried ACE(I/I) genotype (OR 3.38; p=0.019; 57.5% vs. 42.5%; p=0.013). Conclusion: The presence of D allele of ACE can be important independent risk factor in the onset of CAD patients less than 55. years old in a west population of Iran. Larger collaborative studies are needed to confirm these results.

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