The aspergillus fumigatus p-type golgi apparatus Ca 2+ /Mn 2+ ATPase pmra is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis

Nadthanan Pinchai, Praveen Rao Juvvadi, Jarrod Fortwendel, B. Zachary Perfect, Luise E. Rogg, Yohannes G. Asfaw, William J. Steinbach

Research output: Contribution to journalComment/debate

21 Citations (Scopus)

Abstract

The Aspergillus fumigatus δpmrA (Golgi apparatus Ca 2+ /Mn 2+ P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased β-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity.

Original languageEnglish (US)
Pages (from-to)472-476
Number of pages5
JournalEukaryotic Cell
Volume9
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Aspergillus fumigatus
Golgi Apparatus
Cell Wall
Cations
Homeostasis
Chitin
Glucans
Calcineurin
Adenosine Triphosphatases
Growth
Genes
manganese ATPase

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

Cite this

The aspergillus fumigatus p-type golgi apparatus Ca 2+ /Mn 2+ ATPase pmra is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis . / Pinchai, Nadthanan; Juvvadi, Praveen Rao; Fortwendel, Jarrod; Zachary Perfect, B.; Rogg, Luise E.; Asfaw, Yohannes G.; Steinbach, William J.

In: Eukaryotic Cell, Vol. 9, No. 3, 01.03.2010, p. 472-476.

Research output: Contribution to journalComment/debate

Pinchai, Nadthanan ; Juvvadi, Praveen Rao ; Fortwendel, Jarrod ; Zachary Perfect, B. ; Rogg, Luise E. ; Asfaw, Yohannes G. ; Steinbach, William J. / The aspergillus fumigatus p-type golgi apparatus Ca 2+ /Mn 2+ ATPase pmra is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis In: Eukaryotic Cell. 2010 ; Vol. 9, No. 3. pp. 472-476.
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