The association between insulin resistance and atrial fibrillation: A cross-sectional analysis from SPRINT (Systolic Blood Pressure Intervention Trial)

the SPRINT Study Research Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

It is unclear whether metabolic syndrome (MetS) is associated with atrial fibrillation (AF) in an older population with greater cardiovascular risk, including those with chronic kidney disease. The authors investigated the association between MetS and AF in participants in SPRINT (Systolic Blood Pressure Intervention Trial). MetS was defined based on the Modified Third National Cholesterol Education Program. The baseline prevalence rate for MetS was 55%, while 8.2% of the participants had AF. In multivariate regression analyses, AF was not associated with presence of MetS in either chronic kidney disease or non–chronic kidney disease subgroups. Age, race, history of cardiovascular diseases, decreased triglycerides, decreased pulse pressure, and albuminuria remained significantly associated with AF risk. In contrast to the general population, MetS was not associated with AF in the older population with increased cardiovascular risk studied in SPRINT.

Original languageEnglish (US)
Pages (from-to)1152-1161
Number of pages10
JournalJournal of Clinical Hypertension
Volume19
Issue number11
DOIs
StatePublished - Nov 1 2017

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Atrial Fibrillation
Insulin Resistance
Cross-Sectional Studies
Blood Pressure
Chronic Renal Insufficiency
Population
Albuminuria
Kidney Diseases
Triglycerides
Cardiovascular Diseases
Multivariate Analysis
Cholesterol
Regression Analysis
Education

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

The association between insulin resistance and atrial fibrillation : A cross-sectional analysis from SPRINT (Systolic Blood Pressure Intervention Trial). / the SPRINT Study Research Group.

In: Journal of Clinical Hypertension, Vol. 19, No. 11, 01.11.2017, p. 1152-1161.

Research output: Contribution to journalArticle

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abstract = "It is unclear whether metabolic syndrome (MetS) is associated with atrial fibrillation (AF) in an older population with greater cardiovascular risk, including those with chronic kidney disease. The authors investigated the association between MetS and AF in participants in SPRINT (Systolic Blood Pressure Intervention Trial). MetS was defined based on the Modified Third National Cholesterol Education Program. The baseline prevalence rate for MetS was 55{\%}, while 8.2{\%} of the participants had AF. In multivariate regression analyses, AF was not associated with presence of MetS in either chronic kidney disease or non–chronic kidney disease subgroups. Age, race, history of cardiovascular diseases, decreased triglycerides, decreased pulse pressure, and albuminuria remained significantly associated with AF risk. In contrast to the general population, MetS was not associated with AF in the older population with increased cardiovascular risk studied in SPRINT.",
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