The association of conjunctival inflammatory cells with the results of combined cataract extraction and filtration surgery

Tod Mcmillan, William C. Stewart, Hugh L. Hennis, David R. Gwynn

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We studied conjunctival biopsy specimens from 30 consecutive patients undergoing combined cataract extraction with posterior chamber lens implantation and trabeculectomy to determine if inflammatory cell counts and tissue structure are predictive for postoperative intraocular pressure control. We classified intraocular pressure control postoperatively by grouping patients in three ways: first, by ease of intraocular pressure control (patients with <16 mm Hg receiving from no medicine to two glaucoma medicines vs. those with ≥16 mm Hg or receiving three glaucoma medicines); second, by those who had improved versus worsened intraocular pressure control postoperatively compared to before surgery; and third, by those who had bleb elevation versus no bleb formation. With all three classifications no statistical difference existed between groups of patients in the number of goblet cells, mast cells, neutrophils, eosinophils, macrophages, plasma cells, lymphocytes, or fibroblasts, as well as in epithelium thickness or vascular density (p > 0.05, Student’s t test). Also, no statistical difference existed in mucopolysaccharide or collagen staining between groups of patients (p > 0.05, Mann-Whitney U test). This study suggests that conjunctival inflammatory cell counts or tissue structure, which can be evaluated histologically, are not associated with postoperative intraocular pressure control following combined cataract extraction and trabeculectomy.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalJournal of Glaucoma
Volume2
Issue number3
StatePublished - Jan 1 1993
Externally publishedYes

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Filtering Surgery
Cataract Extraction
Intraocular Pressure
Trabeculectomy
Cell Count
Nonparametric Statistics
Glycosaminoglycans
Lenses
Collagen
Staining and Labeling
Students
Biopsy

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

The association of conjunctival inflammatory cells with the results of combined cataract extraction and filtration surgery. / Mcmillan, Tod; Stewart, William C.; Hennis, Hugh L.; Gwynn, David R.

In: Journal of Glaucoma, Vol. 2, No. 3, 01.01.1993, p. 193-199.

Research output: Contribution to journalArticle

Mcmillan, Tod ; Stewart, William C. ; Hennis, Hugh L. ; Gwynn, David R. / The association of conjunctival inflammatory cells with the results of combined cataract extraction and filtration surgery. In: Journal of Glaucoma. 1993 ; Vol. 2, No. 3. pp. 193-199.
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