The bacterial and host factors associated with extrapulmonary dissemination of Mycobacterium tuberculosis

Dong Yang, Ying Kong

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

With high morbidity and mortality worldwide, tuberculosis (TB) is still an important public health threat. The majority of human TB cases are caused by Mycobacterium tuberculosis. Although pulmonary TB is the most common presentation, M. tuberculosis can disseminate into other organs and causes extrapulmonary TB (EPTB). The dissemination of bacteria from the initial site of infection to other organs can lead to fatal diseases, such as miliary and meningeal TB. Thoroughly understanding the mechanisms and pathways of dissemination would develop therapies to prevent the lethal prognosis of EPTB (miliary and meningeal TB) and vaccines to promote the development of adaptive immunity. This review focuses on risk factors of EPTB, bacterial and host genes involved in EPTB, and potential mechanisms of M. tuberculosis extrapulmonary dissemination.

Original languageEnglish (US)
Pages (from-to)252-261
Number of pages10
JournalFrontiers in Biology
Volume10
Issue number3
DOIs
StatePublished - Jun 27 2015

Fingerprint

tuberculosis
Mycobacterium tuberculosis
Miliary Tuberculosis
Meningeal Tuberculosis
Tuberculosis
Tuberculosis Vaccines
Bacterial Genes
Adaptive Immunity
Pulmonary Tuberculosis
Public Health
Morbidity
Bacteria
Mortality
Infection
lethal genes
prognosis
morbidity
public health
risk factors
lungs

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Genetics

Cite this

The bacterial and host factors associated with extrapulmonary dissemination of Mycobacterium tuberculosis. / Yang, Dong; Kong, Ying.

In: Frontiers in Biology, Vol. 10, No. 3, 27.06.2015, p. 252-261.

Research output: Contribution to journalReview article

@article{fce7b9197dfb499abec5ff9daaa8490d,
title = "The bacterial and host factors associated with extrapulmonary dissemination of Mycobacterium tuberculosis",
abstract = "With high morbidity and mortality worldwide, tuberculosis (TB) is still an important public health threat. The majority of human TB cases are caused by Mycobacterium tuberculosis. Although pulmonary TB is the most common presentation, M. tuberculosis can disseminate into other organs and causes extrapulmonary TB (EPTB). The dissemination of bacteria from the initial site of infection to other organs can lead to fatal diseases, such as miliary and meningeal TB. Thoroughly understanding the mechanisms and pathways of dissemination would develop therapies to prevent the lethal prognosis of EPTB (miliary and meningeal TB) and vaccines to promote the development of adaptive immunity. This review focuses on risk factors of EPTB, bacterial and host genes involved in EPTB, and potential mechanisms of M. tuberculosis extrapulmonary dissemination.",
author = "Dong Yang and Ying Kong",
year = "2015",
month = "6",
day = "27",
doi = "10.1007/s11515-015-1358-y",
language = "English (US)",
volume = "10",
pages = "252--261",
journal = "Frontiers of Biology in China",
issn = "1673-3509",
publisher = "Higher Education Press",
number = "3",

}

TY - JOUR

T1 - The bacterial and host factors associated with extrapulmonary dissemination of Mycobacterium tuberculosis

AU - Yang, Dong

AU - Kong, Ying

PY - 2015/6/27

Y1 - 2015/6/27

N2 - With high morbidity and mortality worldwide, tuberculosis (TB) is still an important public health threat. The majority of human TB cases are caused by Mycobacterium tuberculosis. Although pulmonary TB is the most common presentation, M. tuberculosis can disseminate into other organs and causes extrapulmonary TB (EPTB). The dissemination of bacteria from the initial site of infection to other organs can lead to fatal diseases, such as miliary and meningeal TB. Thoroughly understanding the mechanisms and pathways of dissemination would develop therapies to prevent the lethal prognosis of EPTB (miliary and meningeal TB) and vaccines to promote the development of adaptive immunity. This review focuses on risk factors of EPTB, bacterial and host genes involved in EPTB, and potential mechanisms of M. tuberculosis extrapulmonary dissemination.

AB - With high morbidity and mortality worldwide, tuberculosis (TB) is still an important public health threat. The majority of human TB cases are caused by Mycobacterium tuberculosis. Although pulmonary TB is the most common presentation, M. tuberculosis can disseminate into other organs and causes extrapulmonary TB (EPTB). The dissemination of bacteria from the initial site of infection to other organs can lead to fatal diseases, such as miliary and meningeal TB. Thoroughly understanding the mechanisms and pathways of dissemination would develop therapies to prevent the lethal prognosis of EPTB (miliary and meningeal TB) and vaccines to promote the development of adaptive immunity. This review focuses on risk factors of EPTB, bacterial and host genes involved in EPTB, and potential mechanisms of M. tuberculosis extrapulmonary dissemination.

UR - http://www.scopus.com/inward/record.url?scp=84933179103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84933179103&partnerID=8YFLogxK

U2 - 10.1007/s11515-015-1358-y

DO - 10.1007/s11515-015-1358-y

M3 - Review article

VL - 10

SP - 252

EP - 261

JO - Frontiers of Biology in China

JF - Frontiers of Biology in China

SN - 1673-3509

IS - 3

ER -