The brain processing of scratching

Gil Yosipovitch, Yozo Ishiuji, Tejesh Patel, Maria Isabel Hicks, Yoshitetsu Oshiro, Robert A. Kraft, Erica Winnicki, Robert C. Coghill

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Neuroimaging studies have examined the neural networks activated by pruritus but not its behavioral response, scratching. In this study, we examine the central sensory effects of scratching using blood oxygen level-dependent functional magnetic resonance imaging (fMRI) in 13 healthy human subjects. Subjects underwent functional imaging during scratching of the right lower leg. Scratching stimulus was started 60 seconds after initiation of fMRI acquisition and was cycled between 30-second duration applications of scratching and 30-second duration applications of no stimuli. Our results show that repetitive scratching induces robust bilateral activation of the secondary somatosensory cortex, insular cortex, prefrontal cortex, inferior parietal lobe, and cerebellum. In addition, we show that the same stimulus results in robust deactivation of the anterior and posterior cingulate cortices. This study demonstrates brain areas (motor, sensory, and non-sensory) activated and deactivated by repetitive scratching. Future studies that investigate the central effects of scratching in chronic itch conditions will be of high clinical relevance.

Original languageEnglish (US)
Pages (from-to)1806-1811
Number of pages6
JournalJournal of Investigative Dermatology
Volume128
Issue number7
DOIs
StatePublished - Jan 1 2008

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Gyrus Cinguli
Brain
Magnetic Resonance Imaging
Neuroimaging
Parietal Lobe
Somatosensory Cortex
Pruritus
Processing
Prefrontal Cortex
Cerebral Cortex
Cerebellum
Leg
Healthy Volunteers
Blood
Chemical activation
Oxygen
Neural networks
Imaging techniques
Sensorimotor Cortex

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Yosipovitch, G., Ishiuji, Y., Patel, T., Hicks, M. I., Oshiro, Y., Kraft, R. A., ... Coghill, R. C. (2008). The brain processing of scratching. Journal of Investigative Dermatology, 128(7), 1806-1811. https://doi.org/10.1038/jid.2008.3

The brain processing of scratching. / Yosipovitch, Gil; Ishiuji, Yozo; Patel, Tejesh; Hicks, Maria Isabel; Oshiro, Yoshitetsu; Kraft, Robert A.; Winnicki, Erica; Coghill, Robert C.

In: Journal of Investigative Dermatology, Vol. 128, No. 7, 01.01.2008, p. 1806-1811.

Research output: Contribution to journalArticle

Yosipovitch, G, Ishiuji, Y, Patel, T, Hicks, MI, Oshiro, Y, Kraft, RA, Winnicki, E & Coghill, RC 2008, 'The brain processing of scratching', Journal of Investigative Dermatology, vol. 128, no. 7, pp. 1806-1811. https://doi.org/10.1038/jid.2008.3
Yosipovitch G, Ishiuji Y, Patel T, Hicks MI, Oshiro Y, Kraft RA et al. The brain processing of scratching. Journal of Investigative Dermatology. 2008 Jan 1;128(7):1806-1811. https://doi.org/10.1038/jid.2008.3
Yosipovitch, Gil ; Ishiuji, Yozo ; Patel, Tejesh ; Hicks, Maria Isabel ; Oshiro, Yoshitetsu ; Kraft, Robert A. ; Winnicki, Erica ; Coghill, Robert C. / The brain processing of scratching. In: Journal of Investigative Dermatology. 2008 ; Vol. 128, No. 7. pp. 1806-1811.
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