The childhood cancer survivor study

A national cancer institute-supported resource for outcome and intervention research

Leslie L. Robison, Gregory Armstrong, John D. Boice, Eric J. Chow, Stella M. Davies, Sarah S. Donaldson, Daniel M. Green, Sue Hammond, Anna T. Meadows, Ann C. Mertens, John J. Mulvihill, Paul C. Nathan, Joseph P. Neglia, Roger J. Packer, Preetha Rajaraman, Charles A. Sklar, Marilyn Stovall, Louise C. Strong, Yutaka Yasui, Lonnie K. Zeltzer

Research output: Contribution to journalReview article

346 Citations (Scopus)

Abstract

Survival for childhood cancer has increased dramatically over the last 40 years with 5-year survival rates now approaching 80%. For many diagnostic groups, rapid increases in survival began in the 1970s with the broader introduction of multimodality approaches, often including combination chemotherapy with or without radiation therapy. With this increase in rates of survivorship has come the recognition that survivors are at risk for adverse health and quality-of-life outcomes, with risk being influenced by host-, disease-, and treatment-related factors. In 1994, the US National Cancer Institute funded the Childhood Cancer Survivor Study, a multi-institutional research initiative designed to establish a large and extensively characterized cohort of more than 14,000 5-year survivors of childhood and adolescent cancer diagnosed between 1970 and 1986. This ongoing study, which reflects the single most comprehensive body of information ever assembled on childhood and adolescent cancer survivors, provides a dynamic framework and resource to investigate current and future questions about childhood cancer survivors.

Original languageEnglish (US)
Pages (from-to)2308-2318
Number of pages11
JournalJournal of Clinical Oncology
Volume27
Issue number14
DOIs
StatePublished - May 10 2009

Fingerprint

National Cancer Institute (U.S.)
Survivors
Outcome Assessment (Health Care)
Neoplasms
Survival Rate
Survival
Combination Drug Therapy
Radiotherapy
Quality of Life
Health
Research

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

The childhood cancer survivor study : A national cancer institute-supported resource for outcome and intervention research. / Robison, Leslie L.; Armstrong, Gregory; Boice, John D.; Chow, Eric J.; Davies, Stella M.; Donaldson, Sarah S.; Green, Daniel M.; Hammond, Sue; Meadows, Anna T.; Mertens, Ann C.; Mulvihill, John J.; Nathan, Paul C.; Neglia, Joseph P.; Packer, Roger J.; Rajaraman, Preetha; Sklar, Charles A.; Stovall, Marilyn; Strong, Louise C.; Yasui, Yutaka; Zeltzer, Lonnie K.

In: Journal of Clinical Oncology, Vol. 27, No. 14, 10.05.2009, p. 2308-2318.

Research output: Contribution to journalReview article

Robison, LL, Armstrong, G, Boice, JD, Chow, EJ, Davies, SM, Donaldson, SS, Green, DM, Hammond, S, Meadows, AT, Mertens, AC, Mulvihill, JJ, Nathan, PC, Neglia, JP, Packer, RJ, Rajaraman, P, Sklar, CA, Stovall, M, Strong, LC, Yasui, Y & Zeltzer, LK 2009, 'The childhood cancer survivor study: A national cancer institute-supported resource for outcome and intervention research', Journal of Clinical Oncology, vol. 27, no. 14, pp. 2308-2318. https://doi.org/10.1200/JCO.2009.22.3339
Robison, Leslie L. ; Armstrong, Gregory ; Boice, John D. ; Chow, Eric J. ; Davies, Stella M. ; Donaldson, Sarah S. ; Green, Daniel M. ; Hammond, Sue ; Meadows, Anna T. ; Mertens, Ann C. ; Mulvihill, John J. ; Nathan, Paul C. ; Neglia, Joseph P. ; Packer, Roger J. ; Rajaraman, Preetha ; Sklar, Charles A. ; Stovall, Marilyn ; Strong, Louise C. ; Yasui, Yutaka ; Zeltzer, Lonnie K. / The childhood cancer survivor study : A national cancer institute-supported resource for outcome and intervention research. In: Journal of Clinical Oncology. 2009 ; Vol. 27, No. 14. pp. 2308-2318.
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