The clinical and pathologic features of Charcot-Marie-Tooth disease

B. Xiao, Jusheng Xie, Xiaosu Yang, Zhiguo Wu, Jianfeng Xiao, Jing Li

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To study the clinical and pathological features of Charcot-Marie-Tooth disease (CMT). METHODS: The general clinical data, the changes of neuroelectrophysiology and the pathological features of neural and muscular biopsy of 20 CMT patients were comprehensively analyzed. RESULTS: The clinical manifestations in the two types of CMT were nearly the same, but the changes of neuroelectrophysiology and the pathological characteristics of the neural and muscular biopsy in the two types were obviously different. 16 cases of CMT type 1 were characterized by decreased sensory nerve conduction velocity (SNCV < 30 m/s) and are associated with demyelinating hypertrophic neuropathy. 4 cases of CMT tylpe 2 were characterized by normal SNCV and associated with axonopathy. CONCLUSION: Neuroelectrophysiology and neural and muscular biopsy are important for the diagnosis of CMT.

Original languageEnglish (US)
Pages (from-to)736-738
Number of pages3
JournalZhonghua nei ke za zhi [Chinese journal of internal medicine]
Volume41
Issue number11
StatePublished - Jan 1 2002
Externally publishedYes

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Charcot-Marie-Tooth Disease
Biopsy
Neural Conduction

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

The clinical and pathologic features of Charcot-Marie-Tooth disease. / Xiao, B.; Xie, Jusheng; Yang, Xiaosu; Wu, Zhiguo; Xiao, Jianfeng; Li, Jing.

In: Zhonghua nei ke za zhi [Chinese journal of internal medicine], Vol. 41, No. 11, 01.01.2002, p. 736-738.

Research output: Contribution to journalArticle

Xiao, B. ; Xie, Jusheng ; Yang, Xiaosu ; Wu, Zhiguo ; Xiao, Jianfeng ; Li, Jing. / The clinical and pathologic features of Charcot-Marie-Tooth disease. In: Zhonghua nei ke za zhi [Chinese journal of internal medicine]. 2002 ; Vol. 41, No. 11. pp. 736-738.
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