The coevolution of cell senescence and diploid sexual reproduction in unicellular organisms

Yan Cui, Run Sheng Chen, Wing Hung Wong

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In this paper, we investigate the coevolution of diploid sexual reproduction and cell senescence (i.e., cell aging). We use probability analysis, computer simulation, and exact numerical computation to analyze the impacts of deleterious recessive mutations on sexual and asexual reproduction. The main conclusion is that, without cell senescence, the evolutionary advantages of sexual reproduction cannot be realized in unicellular organisms that reproduce both sexually and asexually. Also, cell senescence is found to be useful in the maintenance of sexual reproduction. This result suggests that diploid sexual reproduction was unlikely to establish itself as a widespread reproduction mechanism without the complementary process of cell senescence.

Original languageEnglish (US)
Pages (from-to)3330-3335
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number7
DOIs
StatePublished - Mar 28 2000

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Cell Aging
Diploidy
Reproduction
Asexual Reproduction
Computer Simulation
Maintenance
Mutation

All Science Journal Classification (ASJC) codes

  • General

Cite this

The coevolution of cell senescence and diploid sexual reproduction in unicellular organisms. / Cui, Yan; Chen, Run Sheng; Wong, Wing Hung.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 7, 28.03.2000, p. 3330-3335.

Research output: Contribution to journalArticle

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