The combined effects of prenatal drug exposure and early adversity on neurobehavioral disinhibition in childhood and adolescence

Philip A. Fisher, Barry M. Lester, David S. DeGarmo, Linda L. Lagasse, Hai Lin, Seetha Shankaran, Henrietta S. Bada, Charles R. Bauer, Jane Hammond, Toni Whitaker, Rosemary Higgins

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The negative effects of prenatal substance exposure on neurobiological and psychological development and of early adversity are clear, but little is known about their combined effects. In this study, multilevel analyses of the effects of prenatal substance exposure and early adversity on the emergence of neurobehavioral disinhibition in adolescence were conducted. Neurobehavioral disinhibition has previously been observed to occur frequently in multiproblem youth from high-risk backgrounds. In the present study, neurobehavioral disinhibition was assessed via behavioral dysregulation and poor executive function composite measures. Data were drawn from a prospective longitudinal investigation of prenatal substance exposure that included 1,073 participants followed from birth through adolescence. The results from latent growth modeling analyses showed mean stability but significant individual differences in behavioral dysregulation and mean decline with individual differences in executive function difficulties. Prior behavioral dysregulation predicted increased executive function difficulties. Prenatal drug use predicted the emergence and growth in neurobehavioral disinhibition across adolescence (directly for behavioral dysregulation and indirectly for executive function difficulties via early adversity and behavioral dysregulation). Prenatal drug use and early adversity exhibited unique effects on growth in behavioral dysregulation; early adversity uniquely predicted executive function difficulties. These results are discussed in terms of implications for theory development, social policy, and prevention science.

Original languageEnglish (US)
Pages (from-to)777-788
Number of pages12
JournalDevelopment and Psychopathology
Volume23
Issue number3
DOIs
StatePublished - Aug 1 2011

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Executive Function
Pharmaceutical Preparations
Individuality
Growth
Multilevel Analysis
Public Policy
Parturition
Psychology

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

The combined effects of prenatal drug exposure and early adversity on neurobehavioral disinhibition in childhood and adolescence. / Fisher, Philip A.; Lester, Barry M.; DeGarmo, David S.; Lagasse, Linda L.; Lin, Hai; Shankaran, Seetha; Bada, Henrietta S.; Bauer, Charles R.; Hammond, Jane; Whitaker, Toni; Higgins, Rosemary.

In: Development and Psychopathology, Vol. 23, No. 3, 01.08.2011, p. 777-788.

Research output: Contribution to journalArticle

Fisher, PA, Lester, BM, DeGarmo, DS, Lagasse, LL, Lin, H, Shankaran, S, Bada, HS, Bauer, CR, Hammond, J, Whitaker, T & Higgins, R 2011, 'The combined effects of prenatal drug exposure and early adversity on neurobehavioral disinhibition in childhood and adolescence', Development and Psychopathology, vol. 23, no. 3, pp. 777-788. https://doi.org/10.1017/S0954579411000290
Fisher, Philip A. ; Lester, Barry M. ; DeGarmo, David S. ; Lagasse, Linda L. ; Lin, Hai ; Shankaran, Seetha ; Bada, Henrietta S. ; Bauer, Charles R. ; Hammond, Jane ; Whitaker, Toni ; Higgins, Rosemary. / The combined effects of prenatal drug exposure and early adversity on neurobehavioral disinhibition in childhood and adolescence. In: Development and Psychopathology. 2011 ; Vol. 23, No. 3. pp. 777-788.
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