The complexity of the HIF-1-dependent hypoxic response in breast cancer presents multiple avenues for therapeutic intervention

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

A critical aspect of tumor physiology is the sensation of oxygen in the microenvironment. The oxygen-responsive Hypoxia-Inducible Factor (HIF)-1α protein is a master transcriptional regulator of the hypoxic response, controlling expression of a variety of genes related to metabolism, glucose transport, cell cycle progression, cell migration, multidrug resistance, and angiogenesis. Several studies have demonstrated that over-expression HIF-1α protein in breast cancer correlates with poor prognosis, increased risk of metastasis and decreased survival. Moreover, hypoxic regions of tumors are believed to be the source of tumor cells that are resistant to radiation and chemotherapy. More recently, it has also been proposed that hypoxia stimulates expansion of normal and cancer stem cells. Despite a complete understanding of how HIF-1α impacts breast cancer progression and metastasis, the HIF-1α pathway is ideal for targeting drug design since interfering with a master regulator of the hypoxic response could disrupt multiple downstream processes essential to tumor cell self-renewal, expansion, dissemination, and metastatic colonization.

Original languageEnglish (US)
Title of host publicationPharmaceutical Perspectives of Cancer Therapeutics
PublisherSpringer US
Pages521-558
Number of pages38
ISBN (Print)9781441901309
DOIs
StatePublished - Dec 1 2009

Fingerprint

Hypoxia-Inducible Factor 1
Tumors
Breast Neoplasms
Cells
Neoplasms
Oxygen
Neoplasm Metastasis
Chemotherapy
Neoplastic Stem Cells
Drug Design
Physiology
Multiple Drug Resistance
Therapeutics
Stem cells
Metabolism
Cell Movement
Cell Cycle
Proteins
Genes
Radiation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The complexity of the HIF-1-dependent hypoxic response in breast cancer presents multiple avenues for therapeutic intervention. / Seagroves, Tiffany.

Pharmaceutical Perspectives of Cancer Therapeutics. Springer US, 2009. p. 521-558.

Research output: Chapter in Book/Report/Conference proceedingChapter

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