The contribution of taste bud populations to bitter avoidance in mouse strains differentially sensitive to sucrose octa-acetate and quinine

Steven J. St. John, John Boughter

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Mice of the SWR/J (SW) strain avoid orally delivered sucrose octa-acetate (SOA), whereas the mice of the C3HeB/FeJ (C3) strain are insensitive to SOA. Mice of both strains and of a congenic strain (C3.SW) that shares more than 99% of the C3 genome, were tested in a taste-salient brief-access taste test for responses to SOA and quinine hydrochloride, before and after transection of the glossopharyngeal or chorda tympani nerve, or sham surgery. Prior to surgery, congenic SOA tasters (C3.SWT) were phenotypically identical to the SW strain in avoidance of SOA, but showed a greater reduction in sensitivity after nerve transection. For quinine avoidance, which is thought to be a polygenic trait, SW mice showed the greatest sensitivity to quinine, C3 the least and C3.SWT mice were different from both parental strains, showing intermediate sensitivity. Nerve transections had only a moderate effect on quinine sensitivity, suggesting that both anterior and posterior taste bud fields contribute to behavioral quinine avoidance. These findings are discussed with regard to the distribution in the oral cavity of putative taste receptors for quinine and SOA and the peripheral organization of bitter taste.

Original languageEnglish (US)
Pages (from-to)775-787
Number of pages13
JournalChemical senses
Volume29
Issue number9
DOIs
StatePublished - Dec 1 2004

Fingerprint

Taste Buds
Quinine
Population
Chorda Tympani Nerve
Multifactorial Inheritance
Mouth
sucrose octaacetate
Genome

All Science Journal Classification (ASJC) codes

  • Physiology
  • Sensory Systems
  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

The contribution of taste bud populations to bitter avoidance in mouse strains differentially sensitive to sucrose octa-acetate and quinine. / St. John, Steven J.; Boughter, John.

In: Chemical senses, Vol. 29, No. 9, 01.12.2004, p. 775-787.

Research output: Contribution to journalArticle

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