The cortico-nigral projection in the rat

an anterograde tracing study with biotinylated dextran amine

A. Naito, Hitoshi Kita

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

The projection from the cortex to the substantia nigra (SN) in the rat was studied using the biotinylated dextran amine (BDA) anterograde tracing method. Injections of BDA into the prefrontal cortex consistently yielded labeling of the thin nerve fibers with small boutons in the SN pars compacta (SNc) and the pars reticulata (SNr). The cortico-nigral projection had a loose medio-lateral and rostro-caudal arrangement. Injections of BDA into the precentral lateral, the parietal, the temporal, and the occipital cortices resulted in sparse or no labeling of boutons in the SN. The density of boutons in the most heavily labeled region of the SN was 0.23/103 μm3. For comparison, similar measurement was performed in the cortico-striatal projection. The density of the boutons in the neostriatum was 4.9/103 μm3. This study indicates that the entire prefrontal cortex projects to the SNc and SNr and that the terminal density of this projection is much less than the cortico-striatal projection.

Original languageEnglish (US)
Pages (from-to)317-322
Number of pages6
JournalBrain Research
Volume637
Issue number1-2
DOIs
StatePublished - Feb 21 1994

Fingerprint

Substantia Nigra
Corpus Striatum
Prefrontal Cortex
Neostriatum
Occipital Lobe
Injections
Temporal Lobe
Nerve Fibers
biotinylated dextran amine
Pars Compacta

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

The cortico-nigral projection in the rat : an anterograde tracing study with biotinylated dextran amine. / Naito, A.; Kita, Hitoshi.

In: Brain Research, Vol. 637, No. 1-2, 21.02.1994, p. 317-322.

Research output: Contribution to journalArticle

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