The current role of model-based drug development

Satyendra Suryawanshi, Liping Zhang, Marc Pfister, Bernd Meibohm

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Importance of the field: Current drug discovery and development programs are under growing scrutiny for low productivity and escalating costs. Model-based drug development (MBDD) has been recognized as a promising tool to address some of the related challenges. Areas covered in this review: This review introduces the concept of MBDD and the associated quantitative pharmacology-based iterative 'learn and confirm' paradigm in the drug discovery and development process to provide concise information for rational decision making. It summarizes the evolving role of MBDD in drug development programs and outlines the full armamentarium of modeling and simulation approaches utilized to facilitate its application. What the reader will gain: Different aspects and applications of MBDD are introduced to the reader and illustrated in prime examples. The reader is provided with an understanding of potential applications of MBDD in drug development as well as the associated limitations and challenges in its implementation. Take home message: MBDD is a tool that is increasingly used throughout the drug discovery and development continuum to support fast and rationale decision making and has thereby the potential to accelerate and increase the cost-effectiveness of the drug development process.

Original languageEnglish (US)
Pages (from-to)311-321
Number of pages11
JournalExpert Opinion on Drug Discovery
Volume5
Issue number4
DOIs
StatePublished - Apr 1 2010

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Pharmaceutical Preparations
Drug Discovery
Decision Making
Cost-Benefit Analysis
Pharmacology
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Cite this

The current role of model-based drug development. / Suryawanshi, Satyendra; Zhang, Liping; Pfister, Marc; Meibohm, Bernd.

In: Expert Opinion on Drug Discovery, Vol. 5, No. 4, 01.04.2010, p. 311-321.

Research output: Contribution to journalReview article

Suryawanshi, Satyendra ; Zhang, Liping ; Pfister, Marc ; Meibohm, Bernd. / The current role of model-based drug development. In: Expert Opinion on Drug Discovery. 2010 ; Vol. 5, No. 4. pp. 311-321.
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