The cytologic criteria of malignancy

Andrew H. Fischer, Chengquan Zhao, Qing Kay Li, Karen S. Gustafson, Isam Eldin Eltoum, Rosemary Tambouret, Barbara Dubray-Benstein, Lynnette C. Savaloja, Peter Kulesza

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Cytology and cell biology are two separate fields that share a focus on cancer. Cancer is still diagnosed based on morphology, and surprisingly little is known about the molecular basis of the defining structural features. Cytology uses the smallest possible biopsy for diagnosis by reducing morphologic "criteria of malignancy" to the smallest scale. To begin to develop common ground, members of the American Society of Cytopathology Cell Biology Liaison Working Group classify some of the "criteria of malignancy" and review their relation to current cell biology concepts. The criteria of malignancy are extremely varied, apparently reflecting many different pathophysiologies in specific microenvironments. Criteria in Group 1 comprise tissue-level alterations that appear to relate to resistance to anoikis, alterations in cell adhesion molecules, and loss of apical-basal polarity. Criteria in Group 2 reflect genetic instability, including chromosomal and possibly epigenetic instability. Criteria in Groups 3 are subcellular structural changes involving cytoplasmic components, nuclear lamina, chromatin and nucleoli that cannot be accounted for by genetic instability. Some distinct criteria in Group 3 are known to be induced by cancer genes, but their precise structural basis remains obscure. The criteria of malignancy are not closely related to the histogenetic classification of cancers, and they appear to provide an alternative, biologically relevant framework for establishing common ground between cytologists and cell biologists. To understand the criteria of malignancy at a molecular level would improve diagnosis, and likely point to novel cell physiologies that are not encompassed by current cell biology concepts.

Original languageEnglish (US)
Pages (from-to)795-811
Number of pages17
JournalJournal of Cellular Biochemistry
Volume110
Issue number4
DOIs
StatePublished - Jul 1 2010

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Cytology
Cell Biology
Neoplasms
Biopsy
Nuclear Lamina
Physiology
Anoikis
Cell Adhesion Molecules
Cell Physiological Phenomena
Chromosomal Instability
Chromatin
Neoplasm Genes
Genes
Epigenomics
Tissue

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Fischer, A. H., Zhao, C., Li, Q. K., Gustafson, K. S., Eltoum, I. E., Tambouret, R., ... Kulesza, P. (2010). The cytologic criteria of malignancy. Journal of Cellular Biochemistry, 110(4), 795-811. https://doi.org/10.1002/jcb.22585

The cytologic criteria of malignancy. / Fischer, Andrew H.; Zhao, Chengquan; Li, Qing Kay; Gustafson, Karen S.; Eltoum, Isam Eldin; Tambouret, Rosemary; Dubray-Benstein, Barbara; Savaloja, Lynnette C.; Kulesza, Peter.

In: Journal of Cellular Biochemistry, Vol. 110, No. 4, 01.07.2010, p. 795-811.

Research output: Contribution to journalReview article

Fischer, AH, Zhao, C, Li, QK, Gustafson, KS, Eltoum, IE, Tambouret, R, Dubray-Benstein, B, Savaloja, LC & Kulesza, P 2010, 'The cytologic criteria of malignancy', Journal of Cellular Biochemistry, vol. 110, no. 4, pp. 795-811. https://doi.org/10.1002/jcb.22585
Fischer AH, Zhao C, Li QK, Gustafson KS, Eltoum IE, Tambouret R et al. The cytologic criteria of malignancy. Journal of Cellular Biochemistry. 2010 Jul 1;110(4):795-811. https://doi.org/10.1002/jcb.22585
Fischer, Andrew H. ; Zhao, Chengquan ; Li, Qing Kay ; Gustafson, Karen S. ; Eltoum, Isam Eldin ; Tambouret, Rosemary ; Dubray-Benstein, Barbara ; Savaloja, Lynnette C. ; Kulesza, Peter. / The cytologic criteria of malignancy. In: Journal of Cellular Biochemistry. 2010 ; Vol. 110, No. 4. pp. 795-811.
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