The defibrillation efficacy of high frequency alternating current sinusoidal waveforms in guinea pigs

Scott J. Roberts, Dongxu Guan, Robert Malkin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

There have been few basic studies of alternating current (AC) defibrillation, despite growing interest in the ability of AC to terminate or alter ongoing fibrillation. Based on fibrillation threshold testing, it has been suggested that cardiac tissue is most sensitive to long duration, low strength AC stimulation at around 50 Hz. This has not been directly tested for defibrillation. Two subcutaneous electrodes were placed 40 mm apart on opposing aspects of the guinea pig thorax. Seven seconds were allowed to elapse between fibrillation initiation and defibrillation. The tested waveforms were at 50, 100, 200, 500, and 1000 Hz with 2, 4, 8, 16, and 32-cycles. The efficacy of every waveform was measured using a single stimulus in a large population of animals. Forty-one guinea pigs were used in the fixed energy group. Thirty-three guinea pigs were used in the fixed amplitude group with additional 1-cycle waveforms tested. The 200-Hz und the 2-cycle waveforms were significantly more efficacious than those at other frequencies (P < 0.02) and other durations (P < 0.001). The 50-Hz waveforms were the least successful. Amplitude, not duration or energy, was the determinate of efficacy for 2-cycle (the most efficacious) waveforms. Unlike low strength stimulation, defibrillation strength stimuli are most effective with high frequency (200 Hz) pulses (2 cycles).

Original languageEnglish (US)
Pages (from-to)599-604
Number of pages6
JournalPACE - Pacing and Clinical Electrophysiology
Volume26
Issue number2 I
StatePublished - Feb 1 2003
Externally publishedYes

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Guinea Pigs
Electrodes
Thorax
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

The defibrillation efficacy of high frequency alternating current sinusoidal waveforms in guinea pigs. / Roberts, Scott J.; Guan, Dongxu; Malkin, Robert.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 26, No. 2 I, 01.02.2003, p. 599-604.

Research output: Contribution to journalArticle

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