The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum

J. R. Day, A. T. Frank, J. P. O'Callaghan, Byron Jones, J. E. Anderson

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Testosterone reversed the age-related increase in glial fibrillary acidic protein (GFAP) in the male rat cerebellum, a brain region not generally associated with gonadal steroid hormone sensitivity. This supports the hypothesis that a decrease in circulating testosterone contributes to age-related increase in GFAP. These data also suggest that reductions in circulating gonadal steroids during aging could render the brain more susceptible to neurodegeneration and that hormone replacement therapy might have value in neurodegenerative disease intervention.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalExperimental Neurology
Volume151
Issue number2
DOIs
StatePublished - Jan 1 1998

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Glial Fibrillary Acidic Protein
Cerebellum
Testosterone
Hormone Replacement Therapy
Brain
Gonadal Steroid Hormones
Neurodegenerative Diseases
Steroids

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience

Cite this

The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum. / Day, J. R.; Frank, A. T.; O'Callaghan, J. P.; Jones, Byron; Anderson, J. E.

In: Experimental Neurology, Vol. 151, No. 2, 01.01.1998, p. 343-346.

Research output: Contribution to journalArticle

Day, J. R. ; Frank, A. T. ; O'Callaghan, J. P. ; Jones, Byron ; Anderson, J. E. / The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum. In: Experimental Neurology. 1998 ; Vol. 151, No. 2. pp. 343-346.
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