The effect of furosemide and bumetanide on cerebrospinal fluid formation

Betty P. Vogh, Max Langham

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Complete inhibition of carbonic anhydrase maximally reduces CSF flow 40-60%34. We have confirmed that CSF flow in rabbits may be maximally decreased in this way by acetazolamide 30 mg/kg i.v., but have found only about 20% reduction from control after furosemide at 50 mg/kg i.v. This effect of furosemide is consistent with specific but partial inhibition of carbonic anhydrase of choroid plexus (and perhaps other sites of CSF secretion) based on the affinity of furosemide for carbonic anhydrase. Bumetanide, with 7 times lower affinity for carbonic anhydrase and 14-40 times higher inhibition of renal electrolyte transport processes than furosemide2,18,30, did not decrease CSF flow.

Original languageEnglish (US)
Pages (from-to)171-183
Number of pages13
JournalBrain Research
Volume221
Issue number1
DOIs
StatePublished - Sep 21 1981
Externally publishedYes

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Bumetanide
Carbonic Anhydrases
Furosemide
Cerebrospinal Fluid
Acetazolamide
Choroid Plexus
Electrolytes
Rabbits
Kidney

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

The effect of furosemide and bumetanide on cerebrospinal fluid formation. / Vogh, Betty P.; Langham, Max.

In: Brain Research, Vol. 221, No. 1, 21.09.1981, p. 171-183.

Research output: Contribution to journalArticle

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