The effect of noncritical coronary artery disease on long-term survival

J. H. Crenshaw, F. El-Zeky, R. Vander Zwaag, J. M. Sullivan, K Ramanathan, D. M. Mirvis

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Abstract

This study was designed to determine the impact of noncritical (less than 70% narrowing of the luminal diameter) coronary stenoses on the long-term survival rate of patients with coronary artery disease. The survival rate of 3,342 patients with normal coronary arteries (Group 1A) was compared with that of 2,184 patients with only noncritical stenoses (Group 1B). Similarly, the survival rate of 1,128 patients with one or more critical lesions (Group 2A) was compared with that of 5,944 cases with noncritical plus critical lesions (Group 2B). Patients with noncritical lesions had significantly lower 10-year survival rates (85.8%) than did those with normal coronary arteries (90.1%). However, the difference in survival rate was attributable to older age, male sex, and higher prevalence of cigarette smoking, diabetes mellitus, and hypertension in Group 1B than in Group 1A; presence of noncritical stenoses was not a statistically significant independent determinant of survival. Long-term survival rates of the patients with one or more critical lesions (Group 2A) were equivalent to that of patients with critical stenoses plus one or more noncritical lesions (Group 2B). Therefore, 1) patients with only noncritical stenoses have more risk factors for coronary artery disease than do those with normal coronary arteries; 2) these patients have a reduced long-term survival rate that reflects these risk factors rather than the presence of noncritical lesions; and 3) in patients with critical lesions, the presence of additional noncritical stenoses does not affect the long- term survival rate.

Original languageEnglish (US)
Pages (from-to)7-13
Number of pages7
JournalAmerican Journal of the Medical Sciences
Volume310
Issue number1
DOIs
StatePublished - Jan 1 1995

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Coronary Artery Disease
Survival Rate
Survival
Pathologic Constriction
Coronary Vessels
Coronary Stenosis
Diabetes Mellitus
Smoking
Hypertension

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

The effect of noncritical coronary artery disease on long-term survival. / Crenshaw, J. H.; El-Zeky, F.; Vander Zwaag, R.; Sullivan, J. M.; Ramanathan, K; Mirvis, D. M.

In: American Journal of the Medical Sciences, Vol. 310, No. 1, 01.01.1995, p. 7-13.

Research output: Contribution to journalArticle

Crenshaw, J. H. ; El-Zeky, F. ; Vander Zwaag, R. ; Sullivan, J. M. ; Ramanathan, K ; Mirvis, D. M. / The effect of noncritical coronary artery disease on long-term survival. In: American Journal of the Medical Sciences. 1995 ; Vol. 310, No. 1. pp. 7-13.
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