The effect of normal aging on patterns of local cerebral glucose utilization

David E. Kuhl, E. Metter, Walter H. Riege, Randall A. Hawkins

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

When the fluorine‐18‐labeled fluorodeoxyglucose (18FDG) scan was applied to 40 normal volunteer subjects aged 18 to 78 years, mean local cerebral metabolic rate for glucose (lCMRGlu) declined with advancing age at a faster rate than was reported for mean local cerebral metabolic rate for oxygen. Slopes of decline with age were similar in the centrum semiovale, caudate nucleus, putamen, and overall frontal, temporal, parietal, and occipital cortex. Superior frontal cortex and posterior inferior frontal cortex were exceptions, undergoing more rapid metabolic decline with age than in other parts of the brain. Measurements of the rate constants for transport and phosphorylation processes indicate that their change with aging had no major effect on the measurement of lCMRGlu by the 18FDG method.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalAnnals of Neurology
Volume15
Issue number1 S
DOIs
StatePublished - Jan 1 1984

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Frontal Lobe
Fluorodeoxyglucose F18
Glucose
Occipital Lobe
Parietal Lobe
Caudate Nucleus
Putamen
Temporal Lobe
Healthy Volunteers
Phosphorylation
Oxygen
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

The effect of normal aging on patterns of local cerebral glucose utilization. / Kuhl, David E.; Metter, E.; Riege, Walter H.; Hawkins, Randall A.

In: Annals of Neurology, Vol. 15, No. 1 S, 01.01.1984, p. 133-137.

Research output: Contribution to journalArticle

Kuhl, David E. ; Metter, E. ; Riege, Walter H. ; Hawkins, Randall A. / The effect of normal aging on patterns of local cerebral glucose utilization. In: Annals of Neurology. 1984 ; Vol. 15, No. 1 S. pp. 133-137.
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