The effect of pneumococcal vaccine on the disposition of theophylline

G. C. Cupit, T. H. Self, W. B. Bekemeyer

Research output: Contribution to journalArticle

Abstract

Pneumococcal vaccine is frequently given to chronic obstructive airway disease patients who are maintained on theophylline therapy. Several studies demonstrating the effect of viral and bacterial vaccines on drug metabolism prompted our evaluation of the effect of pneumococcal vaccine on theophylline pharmacokinetics. Six healthy volunteers, acting as their own controls, received 250 mg of theophylline every 8h for 12 days. Plasma area under the concentration-time curves (AUC) were measured on Days 4, 6, and 12. On Day 5 pneumococcal vaccine (0.5 ml) was given intramuscularly. No significant difference in elimination rate constant, AUC, or apparent oral clearance of theophylline was found at one or seven days after vaccine administration. These results indicate that intramuscular pneumococcal vaccine does not alter the pharmacokinetics of theophylline during chronic oral administration.

Original languageEnglish (US)
Pages (from-to)505-507
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume34
Issue number5
DOIs
StatePublished - Sep 1988

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Pneumococcal Vaccines
Theophylline
Pharmacokinetics
Viral Vaccines
Bacterial Vaccines
Chronic Obstructive Pulmonary Disease
Oral Administration
Healthy Volunteers
Vaccines
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

The effect of pneumococcal vaccine on the disposition of theophylline. / Cupit, G. C.; Self, T. H.; Bekemeyer, W. B.

In: European Journal of Clinical Pharmacology, Vol. 34, No. 5, 09.1988, p. 505-507.

Research output: Contribution to journalArticle

Cupit, G. C. ; Self, T. H. ; Bekemeyer, W. B. / The effect of pneumococcal vaccine on the disposition of theophylline. In: European Journal of Clinical Pharmacology. 1988 ; Vol. 34, No. 5. pp. 505-507.
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